| 摘要: |
| 目的 了解超声心动图用于心内膜弹力纤维增生症（Endomyocardial fibroelastosis，EFE）患儿和川崎病（Mucocutaneous lymph node syndrome，MCLS）患儿临床诊断和鉴别诊断的价值，为该临床辅助检查方法的具体使用和病情分析提供理论依据。 方法 2014年1月-2016年12月期间，对我院收治的1756例川崎病患者、1032例心内膜弹力纤维增生症患者、1340例体检中心的健康儿童进行研究，比较三组对象临床症状构成、超声心动图检测结果（LA、RV、LVDd、LVEF、LVFS、E/A）的相互差异，分析EFE和MCLS患儿治疗前后，超声心动图各项检测结果的统计学差异。 结果 增生症组和川崎病组患儿症状（呼吸道感染、发热/多汗、气促/紫绀、乏力、哭闹/烦躁、不进食/体重增加缓慢、肝脏增大、心动过速/心音低钝、心力衰竭）构成的差异均有统计学意义（均有P<0.05），其中增生症（发生率84.97%）和川崎病（发生率75.58%）患儿最主要临床症状均是呼吸道感染；三组对象超声心动图检测（LA、RV、LVDd、LVEF、LVFS、E/A）结果的差异有统计学意义（均有P<0.05），具体进行两两组别之间的比较，增生症组和健康组之间、川崎病组和健康组之间、增生症组和川崎病组之间，各项指标的差异均显示出统计学意义（均有P<0.05）；心内膜弹力纤维增生疾病患者治疗前、后超声心动图检测结果的比较，LA、RV、LVDd、LVEF、LVFS、E/A显示出的差异均有统计学意义（均有P<0.05），具体分析各项指标差异的来源，均为组间因素、时间因素和交互作用的影响（均有P<0.05）。 结论 超声心动图用于心内膜弹力纤维增生症患儿、川崎病患儿、正常婴儿的诊断和鉴别诊断有明显指导作用，同时其具体检测参数可以用于心内膜弹力纤维增生症和川崎病患儿转归过程的评价。 |
| 关键词: 超声心动图 心内膜弹力纤维增生症 川崎病 |
| DOI： |
| 投稿时间：2017-09-18修订日期：2018-10-08 |
| 基金项目:湖北省武汉市卫生计生委2015年度科研计划课题项目（WX16C20） |
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| The application of echocardiography （echocardiography） in endocardial elastic fibrosis and the diagnosis and treatment of patients with kawasaki disease |
| liwei |
| (Wuhan children's hospital affiliated to tongji medical college of huazhong university of science and technology) |
| Abstract: |
| Objective The value of echocardiography for the diagnosis and differential diagnosis of children with EFE and the children of MCLS in kawasaki disease was studied， which provided a theoretical basis for the specific use and disease analysis of the clinical assistant examination method. Methods During January 2014 - December 2016， 1756 cases of kawasaki disease in our hospital， 1032 cases of endocardial elastic fiber hyperplasia patients， 1340 cases of medical center residents health study， comparing three sets of objects， echocardiography results of clinical symptoms constitute （LA， RV， LVDd， LVEF， LVFS， E/A） of the differences between each other， analysis of EFE and MCLS children before and after treatment， ultrasonic cardiogram statistical differences of the various test results. Results Hyperplasia group and the group of children with kawasaki disease symptoms （respiratory tract infection， fever/sweat， shortness of breath/purple purple， fatigue， crying， be agitated， don''t eat/body weight increased slowly， liver， tachycardia/low heart sounds blunt， heart failure） constitute the differences were statistically significant （P < 0.05）， including hyperplasia incidence （84.97%） and children with kawasaki disease incidence （75.58%） is the most important clinical symptoms were respiratory tract infection；Three groups of echocardiography to detect objects （LA， RV， LVDd， LVEF， LVFS， E/A） result of the difference was statistically significant （both P < 0.05）， specific and compared between two groups， hyperplasia group and healthy group between， between kawasaki disease group and healthy group， hyperplasia and kawasaki disease group， the difference of each index showed significant （P < 0.05）；Endocardial elastic fiber hyperplasia disease patients before and after the comparison of testing results of echocardiography， LA， RV， LVDd， LVEF， LVFS， E/A show the differences were statistically significant （P < 0.05）， the concrete analysis of each index difference sources， both for the group factor， time factor and the influence of the interaction between （P< 0.05）. Conclusions Echocardiography for endocardial elastic fiber hyperplasia children， children with kawasaki disease， diagnosis and differential diagnosis of normal infants have significant guiding role， at the same time the specific detection of parameters can be used in the endocardial elastic fiber hyperplasia and children with kawasaki disease outcome of the process of evaluation. |
| Key words: Echocardiogram Endocardial elastic fibrosis Kawasaki disease |
