Objective To explore the diagnostic value and the relationship between the cardiac catheterization findings and Doppler techniques alone or together in atrial septal defect disease associated with pulmonary arterial hypertension patients (ASD-PAH). Methods A total of 75 cases of ASD approved by operation or intervention were retrospectively analyzed, Both Doppler parameters and right cardiac catheterization were performed in all patients in 24 hours. All selected patients were divided into two groups according to mean pulmonary arterial pressure (mPAP) on diagnostic right cardiac catheterization: 43 PAH patients and 32 non-PAH patients. Doppler indexes included the peak of tricuspid regurgitation velocities (VTR ) 、tricuspid annular plane systolic excursion (TAPSE)、isovolumetric contraction time（ICT）、isovolumetric relaxation time（IRT）、ejection time（ET）were measured by Doppler tissue imaging and calculated. Correlation analyses were performed to assess the relation between each Doppler index and the cardiac catheterization findings (sPAP, mPAP and dPAP). Results ①Compared to non-PAH groups, TAPSE、ET were significantly lower (P<0.05), but VTR、PASPTR、ICT+IRT、Tei were significantly higher those in the PAH groups (P<0.05); ②A positive correlation was found between VTR and sPAP, mPAP and dPAP ( P＜0.001), at the cut-off 3.3m/s for diagnosing PAH the sensitivity and specificity were 83% and 72% ; ③Tei was also found to be positively correlated with sPAP, mPAP and dPAP(P＜0.001), at the cut-off 0.51 for diagnosing PAH the sensitivity and specificity were 81%,71%; ④The concurrent use of VTR and Tei index to diagnose PAH the sensitivity and specificity were up to 86% and 93% . Conclusion A variety of Doppler parameters , especially Tei index and VTR can offer a new quantitative diagnostic method, when used in conjunction can obviously increase the sensitivity and specificity of PAH diagnosis.