【】Objective To assess the value of Color Doppler ultrasonography (CDFI) and 128-row dual source CT angiography (DSCTA) in the diagnosis of carotid artery stenosis. Methods 80 cases of carotid stenosis (CAS) including 296 segments in our hospital from October 2014 to March 2017 were selected, and examined by CDFI and DSCTA within one week. The results of CDFI and DSCTA were comparatively analyzed with the results of DSA as a golden. Results The sensitivity, specificity and coincidence rate of CDFI were 87.88%, 93.48% and 90.95% respectively with Kappa=0.895. The difference was not statistically significant (P>0.05). The sensitivity, specificity and coincidence rate of DSCTA were 94.03%, 97.50% and 97.40% respectively with Kappa=0.916. The difference was not statistically significant (P>0.05). Conclusion Color Doppler ultrasonography (CDFI) and 128-row dual source CT angiography (DSCTA) can accurately assess the extent of carotid stenosis with good consistency. CDFI can be used as the first choice for screening of CAS patients because of its rapid, simple, noninvasive and reproducible. DSCTA is not suitable for screening because of its cost and efficiency. It is suitable as a method of further definite diagnosis.