Objective:The value of the clinical application of multimodal ultrasonography in gallbladder puncture tube drainage was investigated.Methods:A group of 240 patients with acute cholecystitis were randomly divided into 3 groups, and A group of 120 patients had A different tube method for gallbladder puncture. Group B 60 cases, 30 routine ultrasound guided the gallbladder puncture catheter, 30 routine intravenous ultrasonography + ultrasound guided the gallbladder puncture catheter; C group of 60 cases, 30 routine intravenous contrast-enhanced ultrasound + ultrasound guided gallbladder drainage tube, 30 routine intravenous contrast-enhanced ultrasound + ultrasound guided gallbladder drainage tube + the drainage pipe ultrasonic imaging, data statistics and analysis of each group.Results:The incidence of complications in group A was compared to the complication rate of replacement. The successful comparison of the success rate of cholecystectomy for the success rate of the cholecystectomy in group B was compared with the angiography of the gallbladder puncture. Via intravenous ultrasound imaging in group C + with ultrasound guided gallbladder drainage tube via intravenous contrast-enhanced ultrasound + ultrasound guided gallbladder drainage tube + compare the imaging effect of the drainage tube, the results had significant difference(p<0.05),with statistical significance.Conclusion:Multimodal contrast-en- hanced ultrasound joint gall bladder drainage tube to reduce the incidence of complications, improve the puncture accuracy, achieve the ideal drainage decompression effect, is worth further clinical application.