Abstract:Objective The purpose of the present systematic review was to evaluate the value of two- or three-dimensional speckle tracking imaging(2D-STI or 3D-STI) for left ventricular systolic function in rheumatoid arthritis (RA) patients. Methods Electronic databases including PubMed、Ovid、Cochrane Library，CNKI、VIP、WanFang were searched for published clinical studies comparing the left ventricular systolic function assessed by 2D-STI or 3D-STI of RA patients and controls. Results Nine studies were included with total of 610 patients and 361 healthy control participants. Meta analysis revealed that left ventricular rejection fraction(LVEF) of RA group is less than LVEF of control group（WMD=－0.99, 95%CI[－1.47，－0.52, P < 0.01）.The left ventricular systolic function global radial strain(GRS) of RA group is less than GRS of the controls (WMD=-2.24,95%CI[-2.84,-1.64]、P<0.01) as well. There are the heterogeneity of global longitudinal strain(GLS, I2=80%，P<0.001) 、global circumferential strain (GCS, I2=87%，P<0.001) and global area strain(GAS, I2=90%，P<0.001) about the nine studies. Conclusion 2D- or 3D-STI has clinical values in evaluation left venticular function in patients with RA.