| 摘要: |
| 摘要：目的 对二维或实时三维斑点追踪成像（2D-STI、实时3D-STI）测评类风湿关节炎（RA）患者左心室收缩功能的效果进行系统评价。方法 计算机检索PubMed、Ovid和Cochrane Library、CNKI、万方、维普等数据库，纳入国内外2D-STI或实时3D-STI评价RA患者左心室收缩功能的对照研究。检索时间截止在2017年5月15日。根据纳入与排除标准筛选文献，提取各项数据和评价质量。通过Revman5.3软件分析权重均数差（WMD）及95%可信区间（CI）。结果 最终纳入9篇临床研究，共计610例RA患者和361名正常对照者。RA组较对照组左心室射血分数降低（WMD=－0.99,95%CI[－1.47.－0.52],P<0.01 ）；左心室整体应变中径向应变同质性较好，RA组左心室整体径向应变也小于对照组（WMD=-2.24,95%CI[-2.84,-1.64]、P<0.01），整体纵向应变异质性(I2=80%，P<0.001)较大，可能来源于纳入文献的研究质量，整体环向应变异质性较大(I2=87%，P<0.001)与整体面积应变异质性较大(I2=90%，P<0.001)，异质性来源不明。结论 2D-STI或3D-STI评价RA患者左心室功能具有一定的临床价值。 |
| 关键词: 斑点追踪 类风湿关节炎 左心室心肌应变 Meta分析 |
| DOI： |
| 投稿时间：2017-11-28修订日期：2018-01-09 |
| 基金项目:新疆维吾尔自治区自然科学基金面上项目，编号：2015211C147 |
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| Assessment of left ventricular systolic function myocardial strain by two- or three-dimensional speckle tracking imaging in patients with Rheumatoid Arthritis: Meta analysis |
| TANG Li,LI Hua |
| (Department of Echocardiography of The Affiliated TCM Hospital of Xinjiang Medical University) |
| Abstract: |
| Abstract:Objective The purpose of the present systematic review was to evaluate the value of two- or three-dimensional speckle tracking imaging(2D-STI or 3D-STI) for left ventricular systolic function in rheumatoid arthritis (RA) patients. Methods Electronic databases including PubMed、Ovid、Cochrane Library，CNKI、VIP、WanFang were searched for published clinical studies comparing the left ventricular systolic function assessed by 2D-STI or 3D-STI of RA patients and controls. Results Nine studies were included with total of 610 patients and 361 healthy control participants. Meta analysis revealed that left ventricular rejection fraction(LVEF) of RA group is less than LVEF of control group（WMD=－0.99, 95%CI[－1.47，－0.52, P < 0.01）.The left ventricular systolic function global radial strain(GRS) of RA group is less than GRS of the controls (WMD=-2.24,95%CI[-2.84,-1.64]、P<0.01) as well. There are the heterogeneity of global longitudinal strain(GLS, I2=80%，P<0.001) 、global circumferential strain (GCS, I2=87%，P<0.001) and global area strain(GAS, I2=90%，P<0.001) about the nine studies. Conclusion 2D- or 3D-STI has clinical values in evaluation left venticular function in patients with RA. |
| Key words: two- or three-dimensional speckle tracking rheumatoid arthritis Left ventricular strain Meta-analysis |
