Contrast-enhanced ultrasound (CEUS) is a new ultrasonic diagnostic technology, which can display the internal blood flow and microcirculation status of lesions in real time. It is effective in the differential diagnosis and ultrasound-guided biopsy of tumors. It has been widely used in the fields of liver, kidney, superficial organ diseases and so on. In recent years, CEUS has been gradually applied in the diagnosis of orbital space-occupying lesions and accumulated some experience. This review summarizes the application and development of CEUS in the diagnosis of orbital occupying lesions.