Objective: To explore the value of ARFI in children with Glomerular disease .Methods: Totally 228 cases diagnosed with glomerular disease who accepted the renal biopsy and confirmed by pathological and 200 healthy children underwent acoustic radiation force impulse imaging (ARFI) and serological tests respectively, shear wave velocity (SWV) values were compared among different serological indexes and degree of renal damage ; to explore the clinical value of SWV value evaluate glomerular disease renal damage in children. Results: SWV of glomerular disease group and normal kidney had no significant differences (P > 0.05); there were no significant differences of SWV among group of renal glomerular disease renal damage and different serological test results ( P > 0.05).Conclusion: ARFI technology have some limitations in the assessment of the early glomerular disease in children, and application prospect of ARFI in the terminal stage of chronic kidney disease needs further exploration.