Three-dimensional (3D) printing technology is a newly developed technology in recent years. With the development of 3D ultrasound, ultrasound-derived 3D printing technology is gradually being applied in the diagnosis and treatment of cardiovascular diseases. 3D printing technology can convert 3D ultrasound images into physical models through image acquisition, virtual model reconstruction and physical printing three steps. At present, ultrasound-derived 3D printing technology is mainly used in left atrial appendage (LAA) occlusion, valvular heart disease and congenital heart disease. It is helpful for preoperative evaluation, preoperative simulation surgery, medical device design, hemodynamic simulation. The application prospect of 3D printing technology is broad. The future direction will apply 3D printed bioactive tissue or structure to the human body directly. In order to make 3D printing technology to better serve the clinical, we still face a huge challenge.