【】Objective To evaluate perfusion characteristics of contrast-enhanced ultrasonography(CEUS)and the types and characteristics of dynamic vascular pattern curve(DVPC)of enlarged cervical lymph nodes. Methods In a prospective study CEUS was performed in 95 patients with cervical lymph node enlargement. The SonoLiver software was used to get DVPC. Perfusion characteristics of CEUS and the types and characteristics of DVPC were compared with the histology(reactive lymph node, metastatic lymph node and lymphoma).Results The differences of CEUS perfusion characteristics including perfusion pattern(centripetal enhancement, centrifugal enhancement, chaotic enhancement ), enhancement homogeneity and perfusion defects were significantly among the three groups(P<0.05). Compared metastatic lymph nodes with reactive lymph nodes, metastatic lymph nodes with lymphoma, differences of DVPC were significantly difference(P<0.05).ConclusionsPerfusion characteristics of CEUS and the type and characteristics of DVPC could provide more information for differential diagnosis of enlarged cervical lymph nodes.