In recent years, the imaging technology of the multimodal ultrasound molecular imaging has developed rapidly,and the key is to construct a multimodal ultrasound molecular probe which can be used in optical, MRI, CT, PET and other imaging techniques. At present, scholars which are from domestic and foreign have made a lot of attempts to build multi-modal ultrasonic molecular contrast medium by using different materials. This paper is based on the above research result statistics，and the advantages and disadvantages of the construction materials and the application prospect are analyzed according to the experimental results and the imaging capability and other aspects,and the conclusion can provide some reference for subsequent related research.