Objective：To evaluate myocardial perfusion of CTO patients by low dose drug stress myocardial contrast echocardiography, in addition to cardiac volumes and ejection fraction. Methods: 46 single CTO patients were divided into reopening group and failed-reopening group based on the results of procedure. All patients were conducted low dose doubutamine stress myocardial contrast echocardiography before PCI and in 6-month follow-up, measuring rest and stress CSI, cardiac volumes and ejection fraction. Results: Compared to result before PCI, reopening group was observed the improvement in ejection fraction (60.00±3.22 vs 62.65±3.58, P = 0.017), and stress CSI (60.00±3.22 vs 62.65±3.58, P = 0.017). And the reopening group was also observed the improvement in ejection fraction（62.65±3.58 vs 57.7±5.61, P = 0.001）and stress CSI（1.38±0.28 vs 1.88±0.53, P = 0.000）compared to failed-reopening group. Conclusions: Cardiac volumes and ejection fraction corresponding with myocardial perfusion in stress status were improved after recanalization of CTO.