| 摘要: |
| 目的：低剂量药物负荷心肌声学造影评估CTO开通对左室容积、射血分数和心肌灌注的影响。方法：46例单支CTO患者根据是否开通分为开通组和未通组，在介入术前和术后6月分别行低剂量多巴酚丁胺负荷心肌声学造影，测定静息和负荷CSI、左室容积和射血分数。结果：开通组术前与术后6月相比，射血分数(60.00±3.22 vs 62.65±3.58, P = 0.017)和负荷CSI(1.67±0.53 vs 1.38±0.28, P = 0.000)均有统计学差异。术后6月开通组与未通组相比，射血分数（62.65±3.58 vs 57.7±5.61, P = 0.001）和负荷CSI（1.38±0.28 vs 1.88±0.53，P = 0.000）均有统计学差异。结论：开通CTO可改善左室容积、射血分数和负荷下心肌灌注。 |
| 关键词: 慢性完全闭塞病变,经皮冠状动脉介入治疗,多巴酚丁胺负荷超声心动图,心肌声学造影 |
| DOI： |
| 投稿时间：2018-01-30修订日期：2018-03-30 |
| 基金项目:解放军总医院科技创新苗圃项目(No.13KMZ01) |
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| The Evaluation of Interventional Therapy Effect of Chronic Total Occlusion by Low Dose Drug Stress Myocardial Contrast Echocardiography |
| Liu Bohan,Zhi Guang |
| (PLA General Hospital) |
| Abstract: |
| Objective：To evaluate myocardial perfusion of CTO patients by low dose drug stress myocardial contrast echocardiography, in addition to cardiac volumes and ejection fraction. Methods: 46 single CTO patients were divided into reopening group and failed-reopening group based on the results of procedure. All patients were conducted low dose doubutamine stress myocardial contrast echocardiography before PCI and in 6-month follow-up, measuring rest and stress CSI, cardiac volumes and ejection fraction. Results: Compared to result before PCI, reopening group was observed the improvement in ejection fraction (60.00±3.22 vs 62.65±3.58, P = 0.017), and stress CSI (60.00±3.22 vs 62.65±3.58, P = 0.017). And the reopening group was also observed the improvement in ejection fraction（62.65±3.58 vs 57.7±5.61, P = 0.001）and stress CSI（1.38±0.28 vs 1.88±0.53, P = 0.000）compared to failed-reopening group. Conclusions: Cardiac volumes and ejection fraction corresponding with myocardial perfusion in stress status were improved after recanalization of CTO. |
| Key words: chronic total occlusion, percutaneous coronary intervention, dobutamine stress echocardiography, myocardial contrast echocardiography |
