| 摘要: |
| 摘要：
目的 比较研究高强度聚焦超声（HIFU）联合无水乙醇注射（PEI）与单独高强度聚焦超声（HIFU）治疗子宫腺肌病两种治疗方式的临床价值。
方法 2013年4月-2016年8月在我院确诊为子宫腺肌病的患者78例，其中31例单纯行HIFU治疗，另外47例对病灶进行PEI后再进行HIFU治疗。比较两组消融的时间、能量、术中反应等，术后1周内行盆腔增强MRI检查判断消融的效果。
结果 两组患者年龄、临床症状、子宫及病灶大小等，差异无统计学意义（P ＞0.05）。两组患者均顺利完成治疗，未出现严重不良反应。HIFU组病灶消融率（47.11±11.2）%低于HIFU联合PEI组（74.64±16.3）%（P＜0.05）。HIFU辐照时间、治疗时间、治疗能量，HIFU联合PEI组均明显低于HIFU组（P＜0.05）。
结论 HIFU联合PEI与单纯HIFU治疗子宫腺肌病具有同样的安全性，但HIFU联合PEI可提高HIFU治疗的效率，并获得更好的消融效果，值得推广，但是对于HIFU与PEI联合消融机制的研究可能不仅是二者简单的叠加，也可能与PEI后声场分布改变、细胞膜对声压及温度的耐受改变有关，尚需要进一步的研究。 |
| 关键词: 高强度聚焦超声,无水乙醇,子宫腺肌病 |
| DOI： |
| 投稿时间：2018-02-24修订日期：2019-04-02 |
| 基金项目:福建省卫计委中青年骨干课题，2017-ZQN-10。 |
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| Clinical application of absolute ethanol in the treatment of adenomyosis with high intensity focused ultrasound |
| DING Gui-sheng,LI Jian-wei |
| (Provincial College of Clinical Medicine, Fujian Medical University Department of Ultrasound, Fujian Provincial Hospital) |
| Abstract: |
| ABSTRACT Objective: To compare the clinical efficacy and safety of high intensity focused ultrasound (HIFU) combined with percutaneous ethanol injection (PEI) and single high intensity focused ultrasound (HIFU) in the treatment of adenomyosis. Methods ：From April 2013 to August 2016 , 78 patients with adenomyosis enrolled, of which 31 cases accepted simple HIFU treatment, the other 47 cases were treated with PEI and then HIFU treatment. To evaluate the treatment outcomes and adverse effects between the two groups. Results ：The safety of the two groups was the same, HIFU combined with PEI group was more effective than HIFU group, the treatment time was shortened and the ablation rate was higher.Conclusion：HIFU combined with PEI and simple HIFU treatment of adenomyosis has the same safety, but HIFU combined with PEI group of clinical results better, worthy of promotion.However, the study of the mechanism of ablation of HIFU and PEI may not only be a simple superposition of the two, but also may be related to the change of sound field distribution after PEI and the change of membrane resistance to sound pressure and temperature, which needs further study. |
| Key words: high intensity focused ultrasound percutaneous ethanol injection adenomyosis |
