| 摘要: |
| 恶性肿瘤是一类死亡率很高的疾病，化疗是其重要的治疗方法之一。应用微泡的声孔效应提高细胞对化疗药物的摄取以增加肿瘤组织局部药物浓度达到增敏化疗的目的，是目前肿瘤治疗研究的新方向之一。超声联合微泡可增加肿瘤组织局部药物浓度、增强细胞毒作用，促进肿瘤细胞凋亡，缩小肿瘤体积，改善肿瘤对化疗药物的耐药性，具有良好的临床应用价值及前景。本文拟从超声联合微泡增敏肿瘤化疗的基础研究及临床运用方面进行综述。 |
| 关键词: 超声 微泡 肿瘤 化疗增敏 |
| DOI： |
| 投稿时间：2018-03-07修订日期：2018-10-08 |
| 基金项目:国家科技计划基金(2017YFC0107300) |
|
| Basic Research and Clinical Application Progress of Ultrasound Combined with Microbubbles in Tumor Chemosensitization |
| WANG Yi-xi,YAN KUN |
| () |
| Abstract: |
| Malignant tumors are a type of disease with high mortality, and chemotherapy is one of the important treatments. The application of microbubble sonoporation effect to increase the uptake of chemotherapeutic drugs by cells to increase the local drug concentration of tumor tissue to achieve the purpose of sensitizing chemotherapy is one of the new directions of tumor treatment research. Ultrasound combined with microbubbles can increase the local drug concentration of tumor tissue, enhance cytotoxicity, promote tumor cell apoptosis, reduce tumor volume, improve tumor resistance to chemotherapeutic drugs, and have good clinical application value and prospect. This paper is intended to summarize the basic research and clinical application of ultrasound combined with microbubbles sensitizing tumor chemotherapy. |
| Key words: Ultrasound Microbubble Tumor Chemosensitization |
