| 摘要: |
| 摘要： 目的 探讨实时超声弹性应变率比值法在评价桥本氏甲状腺炎背景下结节良恶性鉴别诊断中的应用价值。方法 分析186例（231个病灶）经手术病理证实的桥本甲状腺炎（HT）背景下甲状腺结节的超声弹性图像，计算病灶与同侧甲状腺组织的弹性应变率比值（SR），以2.73为临界点判断结节的良恶性。结果 231个HT合并甲状腺结节中，恶性60个，良性171个，恶性结节SR中位数（上、下四分位数）为3.11（5.08，1.89），良性结节SR中位数（上、下四分位数）为1.59（2.17，1.15），二者差异有统计学意义（P<0.001）。以2.73为诊断的最佳临界点，则弹性应变率比值法判断HT背景下结节良恶性的敏感度、特异度、准确性、阳性预测值、阴性预测值分别为60.00%（36/60）、86.55%（148/171）、79.65%(184/231)、61.02%（36/59）。结论 实时超声弹性应变率比值法为鉴别桥本氏甲状腺炎背景下结节的良恶性提供有效帮助，具有一定临床应用价值。 |
| 关键词: 桥本甲状腺炎,实时超声弹性成像,应变率比值 |
| DOI： |
| 投稿时间：2018-03-08修订日期：2018-03-08 |
| 基金项目: |
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| Diagnosis in Benign and Malignant nodules with Hashimoto’s Thyroiditis by Real-time Elastography |
| wufan,HeZheng |
| (Shuguang Hospital, affiliated to Shanghai University of Traditional Chinese Medicine) |
| Abstract: |
| Abstract： Objective To evaluate the clinical value of strain ratio of real-time elastosonography in the diffential diagnosis of thyroid nodules with coexistent chronic Hashimoto’s thyroiditis. Methods This research was conducted via analyzing the elasticity imaging of 186 Hashimoto’s thyroiditis patient with 231 nodules and calculating the stain ratio of each lesion to the same lateral thyroid tissue respectively to determine the benign and malignant diagnosis of nodules based on the cutoff point, 2.73.All the lesions were confirmed by surgery and pathologic examination. Results There were 60 malignant nodules and 171 benign ones in 231 Hashimoto’s thyroiditis with thyroid nodules. The median(upper and lower four digits) of SR of benign and malignant nodules was 3.11(5.08，1.89) and 1.59(2.17，1.15) (P<0.001). When the premier cutoff point was set to 2.73, the sensitivity, specificity, accuracy, PPV and NPV of were 60.00%（36/60）,86.55%(148/171), 79.65%(184/231) and 61.02%（36/59） respectively in differential diagnosis of benign and malignant nodules with Hashimoto’s thyroiditis.Conclution The stain ratio of real time ultrasound elastography put positive effects in the differentialsis of malignant and benign nodules with Hashimoto’s thyroiditis, which can be applied in clinic. |
| Key words: Hashimoto’s thyroiditis,Real-time ultrasound elastography,Strain ratio |
