Objective: To assess the effectiveness and safely of ultrasound guided thrombin injection (UGTI)) to treat iatrogenic femoral pseudoaneurysms. Methods: The study design involved a systematic review of the literature and meta-analysis of comparative studies. The PubMed，EMbase，MEDLINE，the Cochrane Library,CMB and CNKI were searched up to november 2017,to collect the randomized controlled trials（RCTs）about the effectiveness and safely of ultrasound guided compression UGC) versus ultrasound guided thrombin injection (UGTI) to treat iatrogenic femoral pseudoaneurysms.The literature was using RevMan 5.3 software. Results: Six randomized control trials were included in the analysis. Over all 140 and 140 subjects underwent UGC and UGTI respectively. The latter modality resulted in a significantly higher success rate (97.1% vs 67.1%, OR 11.9, 95% CI 4.6-30.4，P<0.01) while the complication rate for both techniques was low (4.3% vs 7.2%, OR 3.27, 95% CI 0.38-27.9，P=0.26>0.05). Conclusion:Available evidence suggests that UGTI is superior in terms of efficacy and as safe as UGC and thus should be used as the primary modality for the treatment of post-catheterization femoral pseudoaneurysms