| 摘要: |
| 目的: 探讨常规超声及实时剪切波弹性超声（shear wave elastography, SWE）成像与甲状腺乳头状癌（papillary thyroid carcinoma, PTC）BRAFV600E基因突变的相关性。方法: 73个经手术证实的PTC结节，分为BRAF突变组和野生组，分析常规超声图像及SWE参数在两组之间的差异。结果: 91.8%（67/73）的PTC结节是BRAF突变型，8.2%（6/73）的PTC结节是BRAF野生型。突变组及野生组的结节在常规超声形态、纵横比、边缘、回声类型、钙化以及血流类型的比较均不具有统计学意义（p＞0.05），SWE参数中结节杨氏模量最大值（Emax）在突变组PTC结节为82.3±43.5Kpa，野生组结节为42.1±15.6Kpa，两组比较p值＜0.05，曲线下面积（AUC）为0.858，当Emax≥40.8 kPa时鉴别PTCBRAF突变和野生型的敏感度、特异度分别为92.5%、66.7%。结论:实时SWE成像Emax测值与PTC患者中BRAF基因突变型具有一定的相关性。 |
| 关键词: 实时剪切波超声弹性成像 杨氏模量最大值（Emax） 甲状腺乳头状癌 BRAF基因 |
| DOI： |
| 投稿时间：2018-04-13修订日期：2018-05-07 |
| 基金项目: |
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| Associations of conventional ultrasonography and shear wave elastography with BRAF mutation in papillary thyroid carcinoma |
| Hang Jing,LiYang |
| () |
| Abstract: |
| OBJECTIVE: To evaluate the utility of conventional ultrasound and shear wave elastography in diagnosing papillary thyroid carcinoma with braf mutation. METHODS: A group of 73 malignant nodules getting BRAF mutation test results were enrolled in our research. We performed grey-scale ultrasound and 2D-SWE examinations before operation. All the nodules were divided into two groups according to the genetic tests. We used statistical software to investigate different parameters between two groups. RESULTS: BRAF mutation were found in 91.8%(67/73) thyroid papillary carcinoma nodules. Parameters of grey-scale sonography between two groups were not statistically significant. SWE measurements were significantly different between two categories. The maximum Young''s modulus value with positive results was 82.3±43.5kPa, as compared with 42.1±15.6kPa in negative results (p<0.05). On ROC curve, the area under the curve (AUC) of the maximum Young''s modulus value was 0.858. Taking 40.8kPa as the threshold of maximum Young''s modulus value, the sensitivity was 92.5% and specificity was 66.7%. CONCLUSIONS: The maximum Young''s modulus value of PTC nodules is correlated with BRAF genetic testing results. |
| Key words: Shear wave elastography(SWE) Maximum Young’s modulus of thyroid nodules Papillary thyroid nodules BRAF gene |
