The progression of diabetic cardiomyopathy can lead to left ventricular dysfunction. Therefore, early assessment of left ventricular function is of great significance in the treatment and prognosis of patients with diabetic cardiomyopathy. Due to the complexity of the left ventricular anatomy, conventional ultrasound techniques are often difficult to accurately assess the changes in left ventricular function. Speckle Three-dimensional speckle-tracking technology for the assessment of myocardial strain parameter is not restricted by the heart movement direction and amplitude, it can be intuitive to track the movement of myocardium in all directions.This article first discusses the feasibility of three-dimensional speckle-tracking technology in the assessment of left ventricular function, and then reviews its assessment of left ventricular function in diabetic cardiomyopathy.