Objective To investigate the diagnostic value of ARFI technology for benign and malignant breast tumors，and further explore the effect of menopausal status on the diagnostic efficiency. Methods One hundred and ninety-one patients （197 lesions），confirmed by histopathology of our hospital, were examined by conventional ultrasonography，static stress elastography and acoustic palpation tissue quantitative technique （VTQ）. The Logistic regression model was used to detect the most valuable indicators for the diagnosis of breast cancer，and the ROC curve was constructed to compare the diagnostic value and to determine the effect of menopause on its diagnostic efficiency. Results Conventional ultrasound detected 55 BI-RADS 3, 120 BI-RADS 4 (including 16 in 4A, 57 in 4B, 47 in 4C), and 22 in BI-RADS 5.There was a significant difference in the elastic score between benign and malignant breast lesions, and the shear wave value （SWV） in the internal area and the marginal area （P＜0.05）.Multivariate logistic regression analysis showed that the elastography score (X1), the internal region SWV value (X2), and the edge region SWV value (X3) entered the regression equation successively: Y=-9.966+0.847X1+1.072X2+1.274X3, its diagnostic sensitivity and specificity were 90.52% and 90.24%. The area under the curve constructed by BI-RADS classification，elastography score, the SWV values of the internal area，and the SWV value of the marginal region are 0.892,0.807,0.926 and 0.927, respectively. Multivariate analysis of variance showed that there was no association between menopausal status，histopathology and the VTQ value （P>0.05）.Conclusion ARFI technology is of high value in the differential diagnosis of benign and malignant breast Tumors, and its diagnostic efficiency might not be affected by menopausal status.