| 摘要: |
| 甲状腺乳头状癌（PTC）的发病率逐年增加，但由于部分PTC不具有典型超声影像学恶性征象、超声引导下细针穿刺细胞学诊断（FNAC）具有一定局限性等原因，术前无法获得明确诊断。近年来的研究倾向于寻找PTC发生、发展的关键分子，应用于FNAC取样标本中进行检测，以提高PTC术前诊断准确率，为病情评估提供分子学依据。本文将对FNAC联合丝/苏氨酸特异性激酶（BRAF）V600E基因突变检测对PTC的诊断及病情评估的研究进展进行综述。 |
| 关键词: 超声引导 细针穿刺细胞学诊断 甲状腺乳头状癌 BRAF V600E基因突变 |
| DOI： |
| 投稿时间：2018-08-21修订日期：2019-03-28 |
| 基金项目:甲状腺乳头状癌的多模态超声成像、FNAC及预警分子的相关研究 |
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| Research progress of BRAF V600E mutation on fine-needle aspiration cytology specimens in papillary thyroid cancer diagnosis and evaluating severity |
| liruoxuan,zhouzubang |
| (Gansu University of Chinese Medicine) |
| Abstract: |
| The incidence of thyroid carcinoma has increased at an accelerating rate in recent years.Because of the lack of typical ultraphonic images and limitation of ultrasound guided fine-needle aspiration cytology in some papillary thyroid cancers，defining preoperative diagnosis can not be acquired sometimes.As a result，researchers tend to find the key molecule about the occurrence and development of papillary thyroid cancer and try to combine this molecule with ultrasound guided fine-needle aspiration cytology to improve the accuracy rate of preoperative diagnosis and to offer a molecular evidence for papillary thyroid cancer evaluating severity.This article reviews the research progress of BRAF V600E mutation on fine-needle aspiration cytology specimens in papillary thyroid cancer diagnosis and evaluating severity. |
| Key words: Ultrasound-guided Fine-needle aspiration cytology Papillary thyroid cancer BRAF V600E mutation |
