| 摘要: |
| 目的 探讨实时剪切波弹性成像及肝纤维化血清学指标评估实验性兔肝纤维化程度的价值。方法 新西兰大白兔48只，随机分成实验组40只（皮下注射四氯化碳橄榄油溶液）；对照组8只（皮下注射生理盐水）。在实验的第4、8、12、16周末分别从实验组随机抽取8只和对照组2只，行肝实时剪切波弹性成像、纤维化血清学指标和病理检查，分析Emean 值及纤维化血清学指标与纤维化病理分期的相关性，并采用ROC曲线评估两者对肝纤维化程度的诊断效能。结果 32只造模成功的大白兔肝脏病理呈不同程度的纤维化。任两期之间Emean值差异具有统计学意义，且Emean 值与肝纤维化分期的相关性大于肝纤维化血清学指标（P＜0.05）。Emean 值诊断肝纤维化分期≥S1、≥S2、≥S3、=S4 的曲线下面积均大于0.90，大于IV型胶原、Ⅲ型前胶原氨基端肽和层粘蛋白，在诊断肝纤维化病理分期≥S2、≥S3、=S4的曲线下面积大于透明质酸，P均＜0.05。Emean值除了与透明质酸值在诊断肝纤维化病理分期≥S1的特异度比较差异无统计学意义外，Emean 值在诊断肝纤维化病理各分期的灵敏度、特异度均大于89%，大于肝纤维化血清学指标，P均＜0.05。结论 实验性兔实时剪切波弹性成像Emean 测值对肝纤维化程度的诊断效能高于肝纤维化血清学指标。 |
| 关键词: 实时剪切波弹性成像，肝纤维化，血清学检查，分期 |
| DOI： |
| 投稿时间：2018-09-13修订日期：2018-10-02 |
| 基金项目: |
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| omparison of real-time shear wave elastography and serum fibrosis markers in evaluating liver fibrosis in rabbits |
| liu qingyu,xue ensheng |
| () |
| Abstract: |
| Objective To evaluate the value of real-time shear wave elastography and serum fibrosis markers in evaluating liver fibrosis in rabbits. Methods A total of 48 New Zealand white rabbits were randomly divided into experimental group (40,subcutaneous injection of CCl4 olive oil solution),control group (8,subcutaneous injection of normal saline).At 4,8,12 and 16 weeks after the experiment,eight rabbits in the experimental group and two rabbit in the control group,were randomly selected for SWE,serum fibrosis markers and pathological examination.An analysis was made to determine whether the Emean value and serum fibrosis markers were correlated with the pathological stages of hepatic fibrosis and evaluate their diagnostic efficiency on the liver fibrosis severities by using the receiver operating characteristic curve. Results The 32 rabbits were successfully molded,and the pathology showed that the hepatic lobules were in varying degrees of fibrosis.The difference of Emean value in each stage was statistically significant,The relevance between Emean value and liver fibrosis stage was greater than that of serum fibrosis markers (P < 0.05).The area under the curve for diagnosing Emean value equal or greater than S1,S2,S3 and S4 were greater than 0.90,is higher than that of the CIV,PIIINP and LN,and is higher than HA in the diagnosis of liver fibrosis equal or greater than S2,S3,S4(P < 0.05). The sensitivity, specificity and accuracy of Emean value for diagonsing significant liver fibrosis were higher than 89%,significantly better than serum fibrosis markers (P < 0.05),except for the specificity of the HA value in the diagnosis of hepatic fibrosis equal or greater than pathological stage. Conclusions The diagnostic efficacy of Emean value measured by SWE of experimental rabbits was higher than that of serum fibrosis markers. |
| Key words: real-time shear wave elastography liver fibrosis serological examination installment |
