【Abstract】Objective To assess the clinical application value of vector flow mapping (VFM) in evaluating the left ventricular diastolic function in systemic lupus erythematosus(SLE) patients. Methods 50 patients with SLE and 50 healthy volunteers were enrolled.The quantitative parameters, including average energy loss(aEL) and circulation were measured. Difference was evaluated with two groups at apical, mid and basal segments at different periods. And correlationship was analyzed between aEL, circulation and E/e’, separately. Results ①Compared to the control group，aEL was higher in SLE groups at three segments of atrial systole(p<0.05).②In SLE groups，circulation in rapid filling phase of anterior mitral valve was lower than the control group, but higher in slow filling phase of posterior mitral valve(p<0.05). ③Intra-group comparison, aEL were different in different segments of same phase or at different phases of same segment(p<0.05).④aEL had a good correlation with E/e’ at basal segment of atrial systole in SLE groups(r1＝0.65，p1<0.01) . Conclusions VFM can be utilized to analyze 1eft ventricular hemodynamics features of SLE patients, it may be a good supplement for assessing cardiac diastolic function and reflect the extent of damage.