Objective The research aimed to compare the clinical value of high-frequency ultrasound with CT scanning in the diagnosis of nasal bone fracture. Methods The preoperative high-frequency ultrasound and CT scanning data of totally 186 nasal bone fracture patients were retrospectively and analysed. The overall detection rate and the positive rate of different types of fractures were compared. Results The overall detection rates of nasal bone fracture by high frequency ultrasound and CT were 91.4% and 94.6%, respectively, with no significant difference. The positive rate of high frequency ultrasound in detecting simple linear fracture (55.4%) was higher than that of CT (48.9%) with statistical significance (P < 0.05); the positive rate of high frequency ultrasound in detecting comminuted fracture (29.6%) was similar to that of CT (27.9%), with no statistical significance. The positive rate of high frequency ultrasonography (6.5%) for complex fracture was lower than that of CT (17.7%), the difference was statistically significant (P < 0.05). Conclusion High-frequency ultrasound is safe, inexpensive and convenient, which can be used as an important supplement to the imaging examination of nasal bone fracture and is worthy of clinical application.