ABSTRACT Objective To assess the value of quantitative parameters of shear wave elastography （SWE） in the differential diagnosis of benign and malignant cutaneous lesions by measuring the Young's modulus value. Methods A total of 72 patients underwent real-time SWE to measure the Young's modulus value.According to pathologic results，ROC curve was drawn to evaluate the best cut-off value in differentiating benign and malignant lesions.Results There were 39 benign lesions and 33 malignant lesions in the total 72 cutaneous lesions.The mean Young's modulus value of benign lesions was（20.3±3.3）kpa，as compared with（38.3±9.2）kpa in malignant lesions（P＜0.05）.On ROC curve，the area under the curve（AUC） of the mean Young's modulus value was 0.914.Taking 30.5 kpa as the threshold of mean Young's modulus value，the sensitivity was 84.85% and specificity was 76.92%.Conclusion The mean Young's modulus value of cutaneous lesions can quantitatively assess the lesions'elasticity.SWE is helpful in differentiating malignant and benign cutaneous lesions.