| 摘要: |
| 摘要：目的 采用Meta分析的方法，评价经直肠超声造影引导下前列腺穿刺对前列腺癌的诊断价值。方法 检索PubMed 、CNKI、Cochrane Library和万方数据库中有关经直肠超声造影引导下前列腺穿刺对前列腺癌诊断的相关文献，检索时间限为从数据库建立到2018年9月3日。由两名研究人员分别进行文献检索，按照纳入排除标准对文献进行筛选与提取。采用诊断性试验准确性评价工具（QUADAS）评价纳入文献的质量，Meta-Disc 1.4软件对其敏感度、特异度、阳性似然比、阴性似然比、诊断比值比进行异质性检验并分析，绘制受试者工作特征（SROC）曲线。结果 最终共20项研究（1997例研究对象）纳入本次Meta分析，经直肠超声造影引导下前列腺穿刺诊断前列腺癌的合并敏感度、特异度分别为0.77 [95%CI (0.74, 0.80)]、0.81 [95%CI (0.79, 0.84)]，阳性似然比、阴性似然比分别为4.53 [95%CI (3.30, 6.22)]、0.29 [95%CI (0.24, 0.35)]，诊断比值比为16.94 [95%CI (10.86, 26.43)]，SROC曲线下面积(AUC)为0.8620，Q*指数为0.7926。结论 经直肠超声造影引导下前列腺穿刺对前列腺癌具有较好的诊断价值。 |
| 关键词: 经直肠超声造影 前列腺癌 诊断 Meta分析 |
| DOI： |
| 投稿时间：2018-10-29修订日期：2019-06-03 |
| 基金项目: |
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| The diagnostic value of transrectal contrast-enhanced ultrasound -guided biopsy for prostate cancer: a meta-analysis |
| sunqian,sunsong |
| () |
| Abstract: |
| Abstract: Objective To systematically review the diagnostic value of transrectal contrast-enhanced ultrasound -guided biopsy for prostate cancer. Methods By searching PubMed, CNKI, Cochrane library and Wanfang database from establishment to 3 September 2018, all of the eligible articles about diagnosis prostate cancer with transrectal contrast-enhanced ultrasound -guided biopsy which conformed to the inclusion and exclusion criteria were harvested. The diagnostic test accuracy evaluation tool (QUADAS) was used to evaluate the quality of the included literature. The Meta-Disc 1.4 software performs heterogeneity testing and analysis on its sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, and diagnostic odds ratio, and plots the receiver operating characteristic (SROC) curve. Results A total of 20articles, 1997 cases were analyzed in this study. The pooled sensitivity, specificity, positive likelihood radio, negative likelihood ratio and diagnostic odds ratio of transrectal contrast-enhanced ultrasound -guided biopsy for prostate cancer were 0.77 [95%CI (0.74, 0.80)], 0.81 [95%CI (0.79, 0.84,)], 4.53 [95%CI (3.30, 6.22)], 0.29 [95%CI (0.24, 0.35)], 16.94 [95%CI (10.86, 26.43)], respectively. The AUC and Q* were 0.8620 and 0.7926. Conclusions Transrectal contrast-enhanced ultrasound -guided biopsy has a good diagnostic value of prostate cancer. |
| Key words: Transrectal contrast-enhanced ultrasound Prostate cancer Diagnosis Meta-analysis |
