Objective: To explore the value of 1.2ml SonoVue dose on perfusion parameters of time-intensity curve of liver occupying lesions.Methods: Ultrasound angiography of 52 cases of 1.2ml and 83 cases of 2.4ml SonoVue was performed. Comparison of main methods of enhancement of arterial phase perfusion in patients with liver mass lesions by contrast-enhanced ultrasound.Time-intensity curve and blood perfusion parameters were generated using QLab9.0 software. Comparison of TIC morphological features of benign and malignant lesions in the liver. Analysis of blood perfusion parameters of liver-occupying lesions and peripheral hepatic parenchyma, and differences in blood perfusion parameters between the two groups of liver-occupying lesions.results: The main enhancements of malignant and benign space-occupying lesions were the same in both doses. The enhancement of malignant space-occupying lesions was mainly holistic and peripheral enhancement, and the peak of CEUS TIC was sharp. There were significant differences in CEUS TIC perfusion parameters AT, TTP, Δt, Ib, Ip, ΔI/Δt between the 1.2ml group and the surrounding liver parenchyma (P<0.05), suggesting that 1.2ml SonoVue dose can be used for liver mass. Identification of lesions and surrounding tissues. Compared with the 2.4ml group, there were significant differences in the TIC perfusion parameters AT, TTP, and Ib between the 1.2ml group and the liver parenchyma (P<0.05). Compared with the 2.4ml group, the CEUS TIC perfusion parameters of the 1.2ml group of HCH were only significantly different (P<0.05), and the CEUS TIC perfusion parameters of liver cancer (HCC and MLC) were only significantly different from the Ib measurement (P< 0.05). conclusion: 1.2ml SonoVue CEUS can display liver lesions well, especially for liver cancer and hemangioma.