| 摘要: |
| 目的：采用荟萃分析评估超声造影对前列腺癌（PCa）的诊断价值。方法：通过检索中国期刊全文数据库（CNKI）、VIP数据库（VIP）、万方数据库、PubMed数据库及Cochrane图书馆，收集超声造影诊断PCa的文献。汇总的受试者工作曲线（sROC）用于分析超声造影对PCa的总体诊断效能，研究人群年龄、PSA水平、样本量及文献质量对诊断效能的影响采用亚组分析。结果：超声造影诊断PCa的总体敏感度为：0.78（95%CI：0.74~0.82）；特异度为：0.78（95%CI：0.72~0.83），sROC曲线下面积为：0.85（95%CI：0.81~0.87）。亚组分析显示： <70岁人群及大样本量的研究报告的灵敏度较高， PSA≥10ng/ml及高质量的文献有较高的灵敏度与特异度。结论：超声造影技术在诊断前列腺癌中有较高优势，但仍需制定统一的操作规范与指南，提高诊断价值。 |
| 关键词: 超声造影 前列腺癌 Meta分析 诊断 |
| DOI： |
| 投稿时间：2018-11-21修订日期：2018-12-26 |
| 基金项目:内蒙古自治区自然科学基金项目（项目编号：2015MS08141） |
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| Meta-analysis of contrast-enhanced ultrasound in the diagnosis of prostate cancer |
| Liang Danyan,Hong hua |
| () |
| Abstract: |
| Objective To evaluate the diagnostic value of contrast-enhanced ultrasound (CEUS) for prostate cancer (PCa) with meta-analysis. Methods Clinical researches on the diagnosis of PCa by CEUS was collected from CNKI, VIP Database, Wanfang Database, PubMed and Cochrane Library. The aggregated receiver operating curve (sROC) was used to analyze the overall diagnostic efficacy, and subgroup analysis was used to analyze the effect of the age, PSA level, sample size, and reports quality on diagnostic performance. Resluts The overall sensitivity of CEUS in the diagnosis of PCa was 0.78 (95% CI: 0.74 ~ 0.82); specificity was 0.78 (95% CI: 0.72 ~ 0.83), and the area under the sROC curve was 0.85 (95% CI: 0.81~0.87). Subgroup analysis showed that the <70-year-old population and large sample size studies were more sensitive, with PSA≥10 ng/ml and high-quality literature with higher sensitivity and specificity. Conclusion CEUS had a high advantage in the diagnosis of PCa, but it is still necessary to develop uniform operating practices and guidelines to improve the diagnostic value. |
| Key words: Contrast ultrasound Prostate cancer Meta analysis Diagnostic |
