Abstract:Purpose To explore the application value of three-dimensional speckle-tracking(3D-STE)in evaluating hypertension patients with and without diastolic dysfunction. Materials and methods We selected a total of 58 essential hypertensive patients with preserved left ventricular ejection fraction (LVEF>50%). Echocardiography revealed no left ventricular diastolic dysfuction 27 out of 58 patients with hypertention (HTDD-negative group) and 31 out of 58 patients had diastolic dysfuction (HTDD-positive group). They were compared to a control group of 30 normotensive subjects. All the selected patients were for routine echocardiography and three-dimensional speckle tracking technique. Then we could obtain the parameters which we wanted, such as GLS(global longitudinal strain), GCS(global circumferential strain) and GRS(global radial strain). Results The absolute value of GLS in hypertensive group was significantly lower than that in control group(P<0.01). GLS is positively correlated with left ventricular mass index (LVMI) (r=0.56, P<0.05). The correlation between GCS ,GRS and LVMI was not significant(P>0.05). Conclusion In hypertensive patients with normal left ventricular systolic function, first damage the most susceptible longitudinally arranged subendocardial myocardial fibres that will result in impaired longitudinal. In hypertension patients with and without diastolic dysfunction, left ventricular endocardial longitudinal myocardium has been damaged resulting in reduced GLS, when diastolic dysfunction occurs GLS will decaese more obviouse .