Objective Exploring the application of acoustic palpation organization quantitative technology (virtual touch Tissue quantification (VTQ) Dynamic detection of shear wave velocity (SWV) changes in non-invasive assessment of acute hepatitis liver damage and predictive prognosis. Methods A total of 42 patients with acute hepatitis (experimental group) and 55 patients with hepatitis B virus (control group) were enrolled as the study subjects. The next day, serum markers such as blood coagulation and liver function biochemistry were collected. Ultrasound was performed on the same day. SWV detection, calculation of ultrasound scores. After 12 weeks of follow-up, liver SWV was measured every 2 weeks until the hospital was discharged (in the improved group) or the continuous progress of total bilirubin (TB) was greater than 10 times the upper limit of normal and prothrombin time activity percentage (PTA). ) ≤ 40% (deterioration group). Results The total success rate of SWV in the two groups was 92.78% (90/97), and 7 cases failed (3 in the experimental group and 4 in the control group). The total number of patients in the survey was 90, and the experimental group was 39. The control group 51 cases. The SWV value of the liver in the experimental group was higher than that in the control group [(1.95±0.78) m/s VS(1.13±0.15) m/s, P<0.05]; the SWV value of the liver in the experimental group was positively correlated with AST, ALT and TB (r= 0.303, 0.415, 0.512, P<0.05), no correlation with GGT, ALP and PTA (r=0.115, 0.109, 0.118, P value>0.05). The SWV of the liver in the worsening group was higher than that in the improved group [(2.35±0.89) m/s VS (1.66±0.78) m/s, P<0.05]. The SWV 2.18m/s was used as the threshold for poor prognosis of acute hepatitis. The sensitivity was 0.82 and the specificity was 0.75. The area under the operating characteristic curve (AUROC) of the prognosis of patients with acute hepatitis was 0.891. The liver SWV was dynamically detected, and the improved group maintained below 1.87 m/s and showed a downward trend, while the worse group continued to be higher than 2.18 m/s. Conclusion The prognosis of patients with acute hepatitis patients with SWV values ??above 2.18 m/s is poor. The use of VTQ technique to detect liver SWV non-invasive evaluation of acute hepatitis patients with high prognosis has high accuracy. Dynamic detection of acute hepatitis liver SWV changes has a better prognosis for patients. Potential clinical application value.