| 摘要: |
| 目的 系统评价阴道超声诊断女性宫颈癌的临床价值。方法 检索CNKI、VIP、WangFang、PubMed、Web of Science等数据库和人工检索相关中文期刊,收集阴道超声与金标准(病理活检)比较诊断宫颈癌的诊断性试验。根据制定的纳入和排除标准对文献进行筛选和提取数据,对纳入的文献使用QUADAS工具评价方法学的质量；采用Meta-DiSc 1.4软件对敏感性(SEN)、特异性(SPE)、阳性似然比(+LR)、阴性似然比(-LR)、诊断比值比(DOR)进行异质性检验和数据合并分析,并绘制受试者曲线(SROC)和计算曲线下面积(AUC)。结果 最终纳入25篇文献,2333例研究对象,Meta分析结果：合并SEN=0.90,[95%CI (0.88,0.91)]；合并SPE=0.95,[95%CI (0.93,0.96)]；合并+LR=10.88,[95%CI (5.47,21.63)]；合并-LR 0.13,[95%CI (0.09,0.18)]；合并DOR= 105.99,[95%CI (44.07,254.89)]；合并AUC为0.9590；Q<sub><sup>*</sup></sub>指数为0.9031。结论 阴道超声对宫颈癌的临床诊断有较高的敏感性(90%)和特异性(95%),对常规筛查和临床诊断具有重要的价值。由于研究的样本量和质量的限制,本研究结论尚需进行大样本量和高质量的研究加以客观验证。 |
| 关键词: 阴道超声 宫颈癌 诊断性试验 Meta分析 |
| DOI： |
| 投稿时间：2018-11-27修订日期：2018-11-27 |
| 基金项目: |
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| Diagnostic value of transvaginal ultrasonography in cervical cancer: a Meta analysis |
| luhuiming |
| (Lu Hui-ming Guanagdong General Hospital Nanhai hospital) |
| Abstract: |
| Objective To systematically review the clinical value of transvaginal ultrasound for diagnosis female cervical carcinoma. Methods To search the databases including CNKI、VIP、WangFang、PubMed、Web of Science and manually related Chinese literature to collect the diagnostic tests of transvaginal ultrasound compared with gold standard (pathological biopsy) in the diagnostic of cervical carcinoma.According the inclusion and exclusion to screen literature and extracted data,the quality of each selected study was evaluated by QUADAS.The Meta-Disc 1.4 software was used to conduct pooling on Sensitivity、specificity、Positive Likelihood Ratio、Negative Likelihood Ratio、Diagnostic Odds Ratio.Heterogeneity test was performed and the summary receiver operating characteristic curve was drawn for area under the curve(AUC). Results A total of 25 literatures involving 2333 patients were finally included.The results of Meta-analysisi:pooled SEN=0.90,[95%CI (0.88,0.91)]；pooled SPE=0.95,[95%CI (0.93,0.96)]；pooled +LR=10.88,[95%CI (5.47,21.63)]；pooled -LR 0.13,[95%CI (0.09,0.18)]；pooled DOR= 105.99,[95%CI (44.07,254.89)]；pooled AUC was 0.9590；Q<sub><sup>*</sup></sub> index was0.9031. Conclusion Transvaginal ultrasound has a high sensitivity (90%) and specificity (95%) in the clinical diagnosis of cervical cancer, which is of significant value for routine screening and clinical diagnosis.Due to the limitation of sample size and quality, the conclusions of this study need to be verified objectively by large sample size and high quality research. |
| Key words: Transvaginal ultrasound Cervical cancer Diagnostic value Meta-analysis |
