ABSTRACT Objective To evaluate left ventricular systolic function and systolic synchrony in children with LVNC by RT-3DE.Materials and Methods 34 children with LVNC were enrolled .They were divided into EF normal group（EF≥55%，25 cases）and EF reduction group（EF＜55%，9 cases）.At the same time，20 healthy children who were consistent with the age，height and weight of the experimental group were selected as the normal control group. The RT-3DE automatically outputs the time - volume curve to obtain the systolic synchrony parameters 16 segments，12 segments and 6 segments（Tmsv -SD，Tmsv-Dif，Tmsv -SD%，Tmsv-Dif%）.Results Compared with the normal control group, the EF normal group had Tmsv-SD、Tmsv-Dif and Tmsv-SD%、Tmsv-Dif% in 16 and 12 segments, and the differences were statistically significant（P＜0.05），while 6 segments were no significant difference（P＞0.05）. The EF reduction group compared with the normal control group, Tmsv-SD、Tmsv-Dif and Tmsv-SD%、Tmsv-Dif% in 16 segments, 12 segments and 6 segments; the differences were statistically significant (P＜0.05); The EF normal group compared with the EF reduction group,Tmsv-SD、Tmsv-Dif and Tmsv-SD%、Tmsv-Dif% in 16 segments were significant difference（P＜0.05）.Conclusion RT-3DE technique is used to evaluate the systolic function and systolic synchrony of LVNC in early stage，and assist pediatrician in selecting the appropriate treatment scheme to manage LVNC children.