| 摘要: |
| 目的 探讨前列腺外腺体积（prostatic outer gland volume，OPV）及前列腺外腺特异性抗原体积密度（outer prostate specific antigen density, OPVD）对灰区前列腺癌（prostate cancer, Pca）的鉴别诊断价值。
方法 选取PSA在4~10 ng/mL的Pca和前列腺增生（benign prostatic hyperplasia, BPH）患者221例。经直肠超声测量前列腺体积（prostatic gland volume，PV）、前列腺内腺体积（inner prostatic gland volume，IPV）和OPV。计算PSA/PV（即PSAD）、PSA/OPV（即OPSAD）和PSA/IPV（即IPSAD）。t检验比较各参数在Pca和BPH患者中的差异。ROC曲线计算OPV和OPSAD对Pca的诊断价值。
结果 Pca组OPV平均（28.72±6.35）mL，OPSAD平均（0.220±0.052）ng/mL2；BPH组OPV平均（17.21±3.14）mL，OPSAD平均（0.369±0.052）ng/mL2，二组差异均有统计学意义（P＜0.05）。Pca组IPV为（15.58±8.34）mL显著小于OPV，IPSAD（0.373±0.04）ng/mL2明显大于OPSAD（P＜0.05）。OPSAD对Pca 具有最高的诊断价值，ROC曲线下面积为0.900，敏感性为89.83%，特异性为85.48%。
结论 Pca患者以OPV增大为主，OPSAD降低。BPH患者IPV增大为主，OPSAD增高。Pca患者OPV显著大于IPV，且OPSAD显著低于IPSAD。OPV和OPSAD对鉴别诊断Pca和BPH具有重要的临床价值。 |
| 关键词: 前列腺 经直肠超声 前列腺癌 前列腺外腺 |
| DOI： |
| 投稿时间：2018-12-01修订日期：2019-01-09 |
| 基金项目: |
|
| Clinical significance of prostate outer gland volume and prostate outer gland volume specific antigen density value as predictors for prostate cancer |
| Shi Dian-shun |
| (Department of Medical Ultrasound,Yiwu Fuyuan Hospital) |
| Abstract: |
| Objective To evaluate the value of the outer gland volume of prostate (OPV) and the prostate outer gland volume specific antigen density (OPSAD) as non-invasive screening and diagnosis method for prostate cancer in a select population. Methods The diagnosis data of 221 subjects with serum PSA 4 to 10 ng/mL were analyzed. The prostate volume (PV), inner prostatic gland volume (IPV), and OPV were measured by transrectal ultrasound. Then the PSAD, prostate inner gland volume specific antigen density (IPSAD), and OPSAD were calculated. t test was used to compare the difference of the parameters between Pca and BPH. ROC curve was used to evaluate the diagnostic performance of OPV and OPSAD. Results The OPV and OPSAD of Pca group was (28.72±6.35) mL and (0.220±0.052) ng/mL2 respectively. The IPV and IPSAD of BPH group was (17.21±3.14) mL and (0.369±0.052) ng/mL2 respectively. There were significantly differences between the groups (P＜0.05). The IPV of Pca group was (15.58±8.34) mL, which was significantly smaller than OPV, and the IPSAD of Pca group was (0.373±0.04) ng/mL2, which was significantly higher than that of OPSAD s (P＜0.05). OPSAD was best for differentiate the Pca and BPH, the area under the curve was 0.900, the sensitivity was 89.83%, and the specificity was 85.48%. Conclusions The Pca patients were characterized with larger OPV and lower OPSAD. While the BPH patients were characterized with larger IPV and higher OPSAD. Pca patients had larger OPV than IPV and lower OPSAD than IPSAD. OPV and OPSAD had high value for differentiating the Pca and BPH. |
| Key words: |
