purpose Two-dimensional layer-specific strain echocardiology evalues the effect of qianyangyuyin(QYYY) granules in subclinical damage of hypertension.Methods There were 41 patients with essential hypertension, including 17 in the control group and 24 in the experimental group. Patients in both groups were treated with conventional western medicine. Experiment group was given oral administration of QYYY granules 10g tid. on this basis. Control group did not give QYYY granules. Both groups were observed for 6 months and underwent transthoracic echocardiography before and after the intervention. The image was imported into the EchoPAC workstation for analysis, left ventricular endocardial longitudinal strain((LSendo)、 mid-myocardial longitudinal strain(LSmid)and epicardial longitudinal strain(LSepi)and the general parameters were obtained,and then statistical analysis was performed．Results LSendo、LSmid and LSepi in the experimental group were significantly higher than those in the control group (P<0.01). The improvement difference of LSendo and LSmid in the experimental group was higher than that in the control group (P<0.05)。Conclusion The subclinical myocardial damage in hypertensive patients can be effectively improved by shingyangyuyin granules. The two-dimensional layer-specific strain echocardiology has important application value in the evaluation of early myocardial injury and the effect of pharmacological intervention.