| 摘要: |
| 摘要：目的：探讨失代偿期肝硬化患者负荷状态下心脏结构和功能的改变。方法：纳入肝硬化失代偿期患者66例和年龄性别匹配的体检健康人员35例。应用超声心动图技术测取患者六分钟台阶实验（6MST）前和实验停止即刻心脏结构功能和血流动力学参数进行分析。结果：1）6MST前，与对照组比较，肝硬化失代偿期病例组LAD、CO增大，IVSTd增厚IVRT和EDT延长，E/ e-sep、 RV-Tei增高， RV-FAC%降低（P all<0.05）。2）6MST后即刻，与对照组相比，肝硬化失代偿期病例组HR变化率%降低，IVRT、EDT、E/e、PRPG、TRPG参数差异加大（P all<0.05）。结论：失代偿期肝硬化患者存在亚临床心肌功能障碍，6MST负荷实验可提高心肌正性变力和变时功能评价和舒张功能异常的检出。 |
| 关键词: 肝硬化失代偿期 超声心动图 心脏结构 心脏功能 六分钟台阶实验 |
| DOI： |
| 投稿时间：2018-12-21修订日期：2019-03-17 |
| 基金项目:四川省教育厅重点项目（12ZA057）：肝脏功能、心血管病变和内皮祖细胞在肝硬化疾患中的相互影响 |
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| Cardiac remodeling and function after stress echocardiography in patients with decompensated cirrhosis |
| Chen yangyang,Yue wensheng |
| (Affiliated Hospital of North Sichuan Medical College) |
| Abstract: |
| Cardiac remodeling and function after stress echocardiography in patients with decompensated cirrhosis
Cheng Yangyang, Yue Wensheng, He Xiuli, Li Yuhan, Zeng Yali, Liu Yanqing, Cui Fangzhao, Guo Zhiyu
1 Ultrasound Department，the Affiliated Hospital of North Sichuan Medical College，Nanchong 637000，China. 2 GE Healthcare Cardiac & Vascular ultrasound Clinic Education Team, Chengdu 611731,China
Abstract Objective: To explore the cardiac structure, function and hemodynamic changes before and after 6-minute step test (6MST) in patients with decompensated cirrhosis. Methods: Sixty-six decompensated cirrhosis patients were recruited from the medical inpatient clinic, and the control group was erolled from a local health exhibition and consisted of 35 age- and sex-matched healthy subjects. The atrioventricular size, wall thickness, systolic and diastolic function and hemodynamic parameters etc. were obtained and analyzed using echocardiography before and after 6MST. Results: 1）In pre-6MST, patients with decompensated cirrhosis had higher left ventricular cardiac output (CO), larger left atrium diameter(LAD), longer isovolumic relaxation time (IVRT) and E wave deceleration time (EDT), higher RV-Tei， peak early diastolic transpulmonary valve pressure gradient (PRPG) and peak systolic transtricuspid pressure gradient (TRPG)，lower RV-FAC% compared with control group (P all<0.05). 2）After immediately 6MST, the difference of IVRT、EDT、E/e、PRPG and TRPG increased between two groups (P all<0.05). Furthermore, patients with decompensated cirrhosis existed lower HR change rate% (P all<0.05). Conclusions: Patients with decompensated cirrhosis had subclinical myocardial dysfunction, The 6MST improved the evaluation of positive inotropic and positive chronotropic and the detection of impaired diastolic function on cardiac damage in patients with decompensated cirrhosis.
Keywords: Decompensated cirrhosis; Echocardiography; 6MST; Cardiac structure; Cardiac function |
| Key words: Decompensated cirrhosis Echocardiography 6MST cardiac structure cardiac function |
