Objective The aim of the study is to evaluate the recovery of the right ventricular systolic function and the remodeling of the right ventricle after percutaneous coronary intervention (PCI) in inferior wall infarction patients by using 2-dimensional speckle tracking imaging (2D-STI) longitudinal strain (LS) parameters and to explore the prevalence and determinants of the right ventricular remodeling. Methods 36 patients diagnosed with inferior wall myocardial infarction (IWMI) and treated with percutaneous coronary intervention were included and followed up in our study. Right ventricular 2D longitudinal strain (LS) and traditional parameters were then analyzed off line. RV remodeling was defined as an increase in RV end-diastolic area ≥20% from baseline to 6 months follow-up. And patients were then divided into remodeling group and non remodeling group. Results Only right ventricular LS parameters showed significant difference between different following time. On admission, LVEF and TAPSE were lower in remodeling group than in the non-remodeling group, at discharge, RVGLS,RVSEPLS, septal LSs , LVEF and TAPSE were lower in remodeling group, at 3-6months following, RVFWLS, free wall LSs were lower, RVEDA was larger in the remodeling group (P＜0.05, respectively). Compared with the non-remodeling group, only differences of the recovery trends of all the septal LSs were significant (P＜0.05, respectively), manifesting that septal LSs in non-remodeling group recovered more rapidly than in the remodeling group. Conclusions The 2D-STI RVLS parameters precisely reflected the impaired RV systolic function in the INFMI patients and appeared to be superior to traditional echocardiographic parameters for the risk stratification of the INFMI patients. Moreover, the recovery of the septum appeared to be associated with the right ventricular remodeling, the slower the septum recovered, the more the right ventricular prone to remodeled.