Objective: To investigate the application of transcranial color-coded duplex sonography(TCCS) in patients with Rheumatoid Arthritis(RA) for detection of cerebral atherosclerotic. Methods:Enrolled 50 cases of RA patients as RA group,Recruited another 50 cases of healthy volunteers as control group.Collected the clinical data,Peak systolic blood flow velocity(PSV),end-diastolic velocity(EDV),pulsative index(PI), resistance index(RI) , average speed(AS), resistance height(RH),tensity degree(TD),pressure index(PI),slowdown index(SI) and vascular load(VI) were computed ,the correlations of the hemodynamic parameters and disease duration in RA patients were analyzed. Results:NO significant difference in PSV,EDV,PI,RI were obtained between RA patients and healthy volunteer(P>0.05). AS、RH、SI、TD in RA patients were significantly lower and PI，、VI markedly higher compared with the control grou(P<0.05,0.01). The disease duration had a positive correlation with PI，and RI (r= 0.385,0.565，P<0.05). Conclusions:Application the TCCS in RA patients with hemodynamic changes of MCA could be a relatively sensitive tool for the detection of cerebral atherosclerotic lesions.This could enable timely intervention for early clinical reference.