| 摘要: |
| 目的：探讨经颅彩色双功能超声（TCCS）在类风湿性关节炎（RA）患者脑动脉硬化早期评估中的应用价值，以降低卒中风险。
方法：选取RA患者和健康体检者各50例，收集临床资料，应用TCCS测量大脑中动脉收缩期峰值速度（PSV）、舒张末期峰值速度（EDV）、搏动指数（PI）、阻力指数（RI），计算收缩期平均速度AS、反弹高度RH、紧张度TD、缓慢指数SI、压力指数PI，、血管负荷VI，并分析RA组血流动力学参数与病程的相关性。
结果：两组间PSV、EDV、PI、RI无明显统计学意义（P＞0.05），RA组AS、RH、SI、TD低于对照组，PI、VI明显高于对照组，差异有统计学意义（P＜0.05、0.01），RA组PI，、VI与病程呈正相关（r＝0.385,0.565，P＜0.05）。
结论：应用TCCS检测RA患者大脑中动脉血流动力学的变化，有助于早期发现RA患者脑动脉硬化，为临床及时干预提供依据。 |
| 关键词: 类风湿性关节炎 经颅彩色双功能超声 大脑中动脉 动脉硬化 |
| DOI： |
| 投稿时间：2019-02-17修订日期：2019-03-12 |
| 基金项目: |
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| Application of TCCS for Assessing Cerebral Artery atherosclerosis in Patients with Rheumatoid Arthritis |
| xiejuanjuan,longxiangdang |
| (Hunan Provincial People,s Hospital/The First Affiliated Hospital of Hunan Normal University) |
| Abstract: |
| Objective: To investigate the application of transcranial color-coded duplex sonography(TCCS) in patients with Rheumatoid Arthritis(RA) for detection of cerebral atherosclerotic.
Methods:Enrolled 50 cases of RA patients as RA group,Recruited another 50 cases of healthy volunteers as control group.Collected the clinical data,Peak systolic blood flow velocity(PSV),end-diastolic velocity(EDV),pulsative index(PI), resistance index(RI) , average speed(AS), resistance height(RH),tensity degree(TD),pressure index(PI),slowdown index(SI) and vascular load(VI) were computed ,the correlations of the hemodynamic parameters and disease duration in RA patients were analyzed.
Results:NO significant difference in PSV,EDV,PI,RI were obtained between RA patients and healthy volunteer(P>0.05). AS、RH、SI、TD in RA patients were significantly lower and PI，、VI markedly higher compared with the control grou(P<0.05,0.01). The disease duration had a positive correlation with PI，and RI (r= 0.385,0.565，P<0.05).
Conclusions:Application the TCCS in RA patients with hemodynamic changes of MCA could be a relatively sensitive tool for the detection of cerebral atherosclerotic lesions.This could enable timely intervention for early clinical reference. |
| Key words: Rheumatoid Arthritis transcranial color-coded duplex sonography middle cerebral artery Artery atherosclerosis |
