Abstract Objective To investigate the application value of shear wave elastography(SWE) in detecting the changes of liver tissue stiffness before and after chemotherapy in patients with breast cancer. Methods SWE examination was performed before chemotherapy, after 4 cycles of chemotherapy, after 8 cycles of chemotherapy in all patient. The maximum, minimum, and mean of Young''S modulus of liver were measured, and the serum test including AST,ALT,ALP,GGT were measured ,and then their differences were compared. Results The maximum、 minimum, and mean of Young''S modulus before chemotherapy were（5.74±0.39）kPa、（4.16±0.28）kPa、（4.91±0.18）kPa respectively, those after 4 cycles of chemotherapy were（5.43±0.25）kPa、（3.85±0.17）kPa、（4.50±0.27）kPa respectively. those after the 8 cycles of chemotherapy were （5.24±0.36）kPa、（3.47±0.26）kPa、（4.28±0.16）kPa respectively. The Young''S modulus of liver after chemotherapy was significantly lower than before chemotherapy, and there was statistical difference (P<0.05). There was significant difference between serum test after chemotherapy including ALT, ALP, GGT and chemotherapy berfore (P<0.05), while AST and chemotherapy had no statistical difference (P>0.05). Before and after the 4 cycles of chemotherapy, the hepatic Young’S modulus value was not correlated with the liver function(P>0.05). After the 8 cycle of chemotherapy, hepatic young''s modulus value was negatively correlated with GGT (r =-0.57,P= 0.035).Conclusion SWE is expected to be a new method , noninvasive and quantitative evaluation to evaluate the changes of liver stiffness before and after breast cancer chemotherapy.