Objective To investigate the clinical characteristics and therapeutic strategies of dobutamine stress echocardiography combined with myocardial angiography. Materials and Methods Retrospective analysis was performed on 305 cases of dobutamine loading myocardial angiography from 2015 to 2017, and the main adverse reactions and treatment measures were recorded. Results Among the 305 patients, 31 had arrhythmia, accounting for 36.5%, followed by hypotension, 15.3%, which occurred most in Peak stage, accounting for 75.3% of adverse reactions, most of which were mild to moderate adverse reactions. Conclusion Although dobutamine loading echocardiography combined with myocardial angiography may cause some adverse reactions, this new technique is safe and feasible in the diagnosis and screening of clinical coronary heart disease as long as adequate preparations are made in the examination process and symptomatic treatment is actively carried out, with a small probability of serious adverse consequences.