| 摘要: |
| 目的 应用实时三维斑点追踪技术（RT3D-STI）评价2型糖尿病患者早期左心室整体各三维应变的改变，同时分析其升主动脉弹性的改变，并探讨两者之间的关系。方法 收集临床确诊的2型糖尿病患者60例（DM组），同时选取34例健康体检者作为对照组。采集左心室心尖全容积图像，应用RT3D-STI软件计算得出两组左心室整体纵行应变（GLS）、左心室整体径向应变（GRS）、左心室整体圆周应变（GCS）、左心室舒张末期容积（LVEDV）、左心室收缩末期容积（LVESV）、左心室射血分数（LVEF）及左心室质量（LVM）等参数。应用M型超声心动图测量升主动脉舒张期最大内径（AoD），收缩期最大内径（AoS），从而计算得出升主动脉应变（AS）、升主动脉硬度指数（AoSI）、升主动脉扩张性（AoDIS）等参数，记录肱动脉血压，并分析左心室整体各三维应变与升主动脉各弹性参数之间的关系。结果 与对照组比较，DM组左心室GLS、GRS和GCS降低(P<0.05)，升主动脉AS、AoDIS降低(P<0.05)，脉压（PP）及升主动脉AoSI增高(P<0.05)；并且DM组左心室整体各三维应变与升主动脉弹性参数之间具有一定
的相关性。结论 RT3D-STI 技术可以早期评价2型糖尿病患者左心室整体收缩功能的改变，在射血分数正常的2型糖尿病患者，左心室整体各三维应变降低，升主动脉弹性受损，并且两者之间具有一定的相关性。 |
| 关键词: 实时三维斑点追踪 糖尿病，2型 左心室 三维应变 升主动脉，弹性 |
| DOI： |
| 投稿时间：2019-03-19修订日期：2019-04-06 |
| 基金项目:常州市卫生计生委重大科技项目(ZD201605) |
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| Assessment of Global Left Ventricular Systolic Function in Type 2 Diabetes Mellitus Patients with Real-time Three-dimensional Ultrasound Speckle Tracking and its Relationship with Ascending Aortic Elasticity |
| songxiangting,yanzining |
| () |
| Abstract: |
| Objective To evaluate the changes of left ventricular global three-dimensional strain in early stage of type 2 diabetes mellitus with real-time three-dimensional echocardiography speckle tracking (RT3D-STI) and to analyze the changes of ascending aorta elasticity, and to explore the relationship between them.Methods Fifty-eight patients with type 2 diabetes mellitus (DM group) were enrolled and 34 healthy subjects were selected as control group. Parameters including global longitudinal strain (GLS), global radial strain (GRS), global circumferential strain (GCS), left ventricular end-diastolic volume (LVEDV), left ventricular end-systolic volume (LVESV), left ventricular ejection fraction (LVEF )and left ventricular mass (LVM) were obtained from cardiac apex full volume images by using RT3D-STI. The parameters of ascending aortic strain (AS), ascending aortic stiffness index (AoSI), ascending aortic dilatation (AoDIS) were calculated by M-mode echocardiography. The brachial artery blood pressure was recorded. And the relationship between the three dimensional strain of the left ventricle and the elastic parameters of the ascending aorta were analyzed. Results: Compared with the control group, the left ventricular GLS, GRS and GCS decreased (P < 0.05), AS and AoDIS decreased (P < 0.05), PP and AoSI increased (P < 0.05) in DM group. And there was weak association between the three dimensional strain of the left ventricle and the elastic parameters of ascending aorta in group DM. Conclusion: RT3D-STI can evaluate the changes of left ventricular systolic function in type 2 diabetes mellitus in early stage. In type 2 diabetes mellitus with normal ejection fraction, the overall three-dimensional strain of left ventricle is decreased and the elasticity of ascending aorta is impaired, and there is a significant but weak correlation between them. |
| Key words: Real time three dimensional speckle tracking Diabetes mellitus,type 2 Left ventricular Three-dimensional strain Ascending aortic ,Elasticity |
