| 摘要: |
| 目的：探讨肝细胞癌(hepatocellular carcinoma,HCC)患者肝切除术后炎症相关标志物(SbiomarkersSofSinflammation)与超声造影参数之间的相关性。方法：收集附属医院术前已行超声造影检查,经手术或穿刺病理证实为HCC 的214例病例。筛选肿瘤标本切片已行白细胞介素8(Interleukin-8,IL-8)、甲胎蛋白(α-fetoprotein,AFP)免疫组化染色的病例作为研究对象,分析超声造影参数(始增时间、达峰时间、峰值加速时间、始增速度及增强速率)与炎症相关标志物之间的关系,分析IL-8、AFP阳性与阴性肝癌与的关系。结果：病灶的始增时间、达峰时间、峰值加速时间小于病灶周围背景肝组织,病灶始增速度、增强速率大于病灶周围背景肝组织,差异有统计学意义(P＜0.05)。IL-8表达阳性率75.70% (162/214),AFP表达阳性率70.56%(151/214)。两者表达呈显著正相关(r=0.252,P=0.003)。IL-8、AFP阴性HCC 的始增时间、达峰时间、峰值加速时间大于IL-8、AFP阳性HCC,差异有统计学意义(P＜0.05)；IL-8、AFP阳性HCC始增速度、增强速率大于IL-8、AFP阴性HCC,差异有统计学意义(P＜0.05)。结论：超声造影可判定肝细胞癌不同血供灌注特征并与IL-8、AFP密切相关,对肝癌诊断与治疗具有重要临床价值。 |
| 关键词: 肝细胞癌 炎症相关标志物 超声造影 白细胞介素8 甲胎蛋白 相关性分析 |
| DOI： |
| 投稿时间：2019-05-05修订日期：2019-12-10 |
| 基金项目: |
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| Correlation between inflammatory markers and ultrasound imaging after hepatectomy in patients with hepatocellular carcinoma |
| liushichu |
| () |
| Abstract: |
| Objective: To investigate the correlation between biomarkers of inflammation and THR parameters in hepatocellular carcinoma (HCC) patients after hepatectomy. Methods:A total of 214 patients with HCC confirmed by surgery or puncture pathology who had received contrast-enhanced ultrasonography before surgery in affiliated hospitals were collected. Screening of tumor specimen section has line of Interleukin 8 (Interleukin - 8, IL - 8)and a tire protein (alpha fetoprotein, AFP) immunohistochemical staining of cases as the research object, analyzing ultrasonic imaging parameters (start time, tmax, peak acceleration time and increasing the speed and enhance the rate of beginning) associated with inflammatory markers, the relationship between the analysis of IL - 8, AFP hepatocellular carcinoma and the relationship between the masculine and feminine.Results: The onset time, peaking time and peak acceleration time of the lesion were less than the background liver tissue around the lesion, and the rate of lesion initiation and enhancement were higher than the background liver tissue around the lesion, with statistically significant difference (P<0.05). The positive rate of il-8 expression was 75.70% (162/214), and the positive rate of AFP expression was 70.56%(151/214). There was a significant positive correlation between the two expressions (r=0.252, P=0.003). The onset time, peaking time and peak acceleration time of il-8 and AFP negative HCC were greater than those of il-8 and AFP positive HCC, with statistically significant differences (P<0.05). IL-8、AFP positive HCC initiation rate, enhancement rate greater than il-8, AFP negative HCC, the difference was statistically significant (P<0.05). Conclusion: Contrast-enhanced ultrasonography can determine the different blood supply and perfusion characteristics of hepatocellular carcinoma and is closely related to il-8 and AFP, which has important clinical value in the diagnosis and treatment of hepatocellular carcinoma. |
| Key words: 【Keywords】Hepatocellular carcinoma biomarkers?of?inflammation Contrast-enhanced ultrasonography Interleukin-8 α-fetoprotein Correlation analysis |
