Objective: To investigate the correlation between biomarkers of inflammation and THR parameters in hepatocellular carcinoma (HCC) patients after hepatectomy. Methods:A total of 214 patients with HCC confirmed by surgery or puncture pathology who had received contrast-enhanced ultrasonography before surgery in affiliated hospitals were collected. Screening of tumor specimen section has line of Interleukin 8 (Interleukin - 8, IL - 8)and a tire protein (alpha fetoprotein, AFP) immunohistochemical staining of cases as the research object, analyzing ultrasonic imaging parameters (start time, tmax, peak acceleration time and increasing the speed and enhance the rate of beginning) associated with inflammatory markers, the relationship between the analysis of IL - 8, AFP hepatocellular carcinoma and the relationship between the masculine and feminine.Results: The onset time, peaking time and peak acceleration time of the lesion were less than the background liver tissue around the lesion, and the rate of lesion initiation and enhancement were higher than the background liver tissue around the lesion, with statistically significant difference (P<0.05). The positive rate of il-8 expression was 75.70% (162/214), and the positive rate of AFP expression was 70.56%(151/214). There was a significant positive correlation between the two expressions (r=0.252, P=0.003). The onset time, peaking time and peak acceleration time of il-8 and AFP negative HCC were greater than those of il-8 and AFP positive HCC, with statistically significant differences (P<0.05). IL-8、AFP positive HCC initiation rate, enhancement rate greater than il-8, AFP negative HCC, the difference was statistically significant (P<0.05). Conclusion: Contrast-enhanced ultrasonography can determine the different blood supply and perfusion characteristics of hepatocellular carcinoma and is closely related to il-8 and AFP, which has important clinical value in the diagnosis and treatment of hepatocellular carcinoma.