Objective To explore value of two methods of sound touch elastography(STE) in diagnosing liver fibrosis in patients with chronic hepatitis B(CHB). Methods From June 2018 to March 2019, 122 patients with CHB were selected in our hospital.The pathological results of liver biopsy were used as diagnostic criteria. All patients were successfully examined by STE, and quantitative data were output. The correlation coefficients of Spearman between the mean,median values and pathological stages were calculated, and the diagnostic performances of the two methods for liver fibrosis was analyzed by receiver operator characteristic(ROC) curve. The area under ROC curve was compared by Z-test. Results The Young’s modulus values of the two methods were similar, and there were significant differences among the pathological staging groups (F=36.894, 28.667，respectively, all P＜0.001); The mean and median values were positively correlated with pathological stages (r=0.641, 0.598, respectively, all P＜0.001). The area under ROC curve of mean values for diagnosing liver fibrosis ≥S2, and cirrhosis S4 was slightly higher than that of the median values, but there was no significant difference between the two groups (all P＞0.05), the area under ROC curve of mean values for diagnosing liver fibrosis ≥S3 was higher than that of median values, and the difference was statistically significant (P＜0.05). Conclusion STE has better diagnostic performance in evaluation of liver fibrosis in patients with CHB, and using the mean values of STE quantitative data to diagnose liver fibrosis can obtain a slightly higher diagnostic value.