| 摘要: |
| 目的 探讨声触诊弹性成像（STE）两种取值方法诊断慢性乙型肝炎(CHB)肝纤维化的应用价值。方法 选取2018年6月至2019年3月在我院就诊的122例CHB患者，以肝组织穿刺病理结果为诊断标准。所有患者均成功进行STE检查，输出定量检测数据，计算均值、中位数两种取值方法与病理分期的Spearman相关系数；通过受试者工作特征(ROC)曲线分析两种取值方法对肝纤维化的诊断效能，曲线下面积(AUC)比较采用Z检验。结果 均值、中位数两种取值方法的肝弹性模量值较接近，在各病理分期组间差异均有统计学意义（F=36.894、28.667，均P＜0.001）；均值、中位数两种取值方法与病理分期呈正相关性（r=0.641、0.598，均P＜0.001）；以均值为取值方法诊断肝纤维化≥S2及肝硬化S4的AUC稍高于以中位数为取值方法，差异无统计学意义（均P＞0.05），以均值为取值方法诊断肝纤维化≥S3的AUC高于以中位数为取值方法，差异有统计学意义（P＜0.05）。结论 STE诊断CHB患者肝纤维化具有一定的应用价值，选择定量检测数据的均值为检查结果，可获得稍高的诊断价值。 |
| 关键词: 超声 弹性成像 慢性乙型肝炎 肝纤维化 取值方法 |
| DOI： |
| 投稿时间：2019-05-13修订日期：2019-05-23 |
| 基金项目:南京军区医学科技创新课题项目面上A类(12MA062) |
|
| Comparative Analysis of Sound Touch Elastography for Assessing Liver FibrosisBy Different Value Methods |
| DONG Bingtian,HUANG Shu |
| (Department of Ultrasound,Chenggong Hospital Affiliated to Xiamen University) |
| Abstract: |
| Objective To explore value of two methods of sound touch elastography(STE) in diagnosing liver fibrosis in patients with chronic hepatitis B(CHB). Methods From June 2018 to March 2019, 122 patients with CHB were selected in our hospital.The pathological results of liver biopsy were used as diagnostic criteria. All patients were successfully examined by STE, and quantitative data were output. The correlation coefficients of Spearman between the mean,median values and pathological stages were calculated, and the diagnostic performances of the two methods for liver fibrosis was analyzed by receiver operator characteristic(ROC) curve. The area under ROC curve was compared by Z-test. Results The Young’s modulus values of the two methods were similar, and there were significant differences among the pathological staging groups (F=36.894, 28.667，respectively, all P＜0.001); The mean and median values were positively correlated with pathological stages (r=0.641, 0.598, respectively, all P＜0.001). The area under ROC curve of mean values for diagnosing liver fibrosis ≥S2, and cirrhosis S4 was slightly higher than that of the median values, but there was no significant difference between the two groups (all P＞0.05), the area under ROC curve of mean values for diagnosing liver fibrosis ≥S3 was higher than that of median values, and the difference was statistically significant (P＜0.05). Conclusion STE has better diagnostic performance in evaluation of liver fibrosis in patients with CHB, and using the mean values of STE quantitative data to diagnose liver fibrosis can obtain a slightly higher diagnostic value. |
| Key words: Ultrasonography Elastography Chronic hepatitis B Liver fibrosis Value methods |
