In recent years ,with the integration of various medical imaging techniques and the rapid development of molecular imaging technology, technologically based on ultrasonic molecular imaging and possessing multiple imaging contrast capabilities, multi-modality ultrasound contrast agents have become a research focus in the field of ultrasound imaging.Multi-modality ultrasound contrast agents not only improve the resolution, sensitivity and contrast of ultrasound imaging, but also surpass the limitations of traditional single imaging diagnoses to a certain extent.Because of these characteristics,multi-modality ultrasound contrast agents?realize the complementary advantages of multiple modes of imaging and have a broad application prospects.This article reviews the current research progress of multi-modality ultrasound contrast agents.