Objective To investigate the differential diagnosis value between inverted papilloma of the bladder (IPB) and bladder urothelial carcinoma(BUC) by comprehensive analysis of multiple parameters on color doppler ultrasonography. Methods ultrasonic appearances of 26 cases with IPB and 59 cases with BUC confirmed by pathology were analyzed retrospectively.Results The maximum diameter,base width,base width / transverse diameter ratio (B / T) and the resistive index(RI) in IPB group were smaller than that in BUC group,while longitudinal / transverse diameter ratio (L / T) and longitudinal / base width(L/B) in IPB group were greater than that in IPB group.The banded tumor,internal fine echogenic foci,blood flow signal of level 0 orⅠwithin tumor were more common in IPB group,while the internal bulky echogenic foci and blood flow signal of level Ⅲ within tumor were more common in BUC group.There was statistically significant difference in the aspects above(P＜0.05).Conclusions Comprehensive analysis of multiple parameters on color doppler ultrasonography is helpful to the differential diagnosis of IPB and BUC.