| 摘要: |
| 目的 通过超声(US)成像和磁共振(MRI)成像系统研究SPIO对微泡造影剂功能的影响。 方法 通过将超顺磁纳米颗粒（SPIO）纳米颗粒与白蛋白包膜微泡进行组装，制备超声（US）/磁共振（MRI）双模态造影剂。通过透射电子显微镜、能谱色散X射线能谱仪和紫外可见光分光光度仪对样品的物理特性进行评估。进一步探讨了SPIO的嵌入浓度对微泡造影剂功能的影响。结果 随着SPIO纳米颗粒浓度的增加，功能性包膜造影剂微泡的超声回波响应强度逐渐增强。由SPIO纳米颗粒的聚集产生的协同磁性效应引起功能性包膜造影剂微泡的横向弛豫率r2增大，比单纯的SPIO纳米颗粒的MRI增强效果更好。 结论 该多功能造影剂可以加强US/MRI成像，有助于进一步完善多功能微泡造影剂的设计方法。 |
| 关键词: 超顺磁纳米颗粒 白蛋白包膜微泡造影剂 多功能微泡造影剂 超声成像 磁共振成像 |
| DOI： |
| 投稿时间：2019-05-30修订日期：2019-06-22 |
| 基金项目:国家自然科学基金项目（面上项目，重点项目，重大项目） |
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| Ultrasonic and magnetic resonance imaging using a kind of multifunctional contrast agent |
| Zhang Dong |
| () |
| Abstract: |
| Objective To investigate the effect of super paramagnetic iron oxide nanoparticles (SPIO) on the function of contrast agent by Ultrasonic(US) and Magnetic Resonance Imaging (MRI). Methods The perluorocarbon-filled albumin-SPIO microbubbles were synthesis with an ultrasonic processor and used as US/MRI multifunctional contrast agents. The physical characterizations were accessed by transmission electron microscopy (TEM), X-ray energy dispersive spectroscopy, and UV-visible light absorption spectrum. The influence of SPIO concentration on the function of contrast agents was further studied by US/MRI. Results The ultrasound echo response will be enhanced with the SPIO concentration increasing. The enchancement of r2 value might be attributed to the synergetic magnetism effect arising from the aggregation and stabilization of multiple SPIOs in microbubble shells. The multifunctional microbubbles may be superior negative MRI contrast agents beyond regular SPIOs. Conclusion The contrast agents could improve the US/MRI resolution and contrast, which is helpful to the design method of the multifunctional microbubble contrast agent. |
| Key words: SPIOs albumin microbubble contrast agent multifunctional microbubble contrast agent ultrasonic imaging magnetic resonance imaging |
