| 摘要: |
| 目的 探讨实时剪切波弹性成像技术评价γ-干扰素对实验性兔肝纤维化治疗效果
的应用价值。方法 随机将大白兔分为肝纤维化造模组，正常对照组，并分别利用四氯化碳
橄榄油溶液、生理盐水进行造模，第8周开始运用γ-干扰素对实验组进行干预治疗。第12
周末对实验组和正常对照组大白兔肝脏行实时剪切波弹性成像、血清学指标和病理组织检查，
分析Emean 值及血清学指标与γ-干扰素干预后的肝脏纤维化病理分期的相关性以及两者
对肝纤维化分期的诊断效能。结果 正常对造组、γ-干扰素干预组、肝纤维化模型组大白兔
肝脏大体标本外观，肝纤维化分期，α-SMA的单位面积浓度有显著差异，差异具有统计学
意义。三个不同剂量γ-干扰素干预组肝脏Emean值均较肝纤维化模型组显著降低（P＜0.05）。
γ-干扰素干预后肝脏Emean值与肝纤维化程度相关性高于血清学指标，呈高度线性相关，
相关系数为(r=0.935，P=0.000)，在评价肝纤维化病理分期≥S1、≥S2、≥S3、=S4的ROC
曲线下面积分别均大于HA、CIV、PⅢNP和LN，敏感性、准确性、特异性均＞88.8%。结论 实
时剪切波弹性成像可对γ-干扰素干预后的肝纤维化分期予以量化评估，能够客观、敏感的
反应γ-干扰素的疗效。 |
| 关键词: 实时剪切波弹性成像，肝纤维化，血清学检查， γ-干扰素 |
| DOI： |
| 投稿时间：2019-06-11修订日期：2019-06-22 |
| 基金项目: |
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| Applied real-time shear wave elastography evaluate the effect of IFN-γ in experimental rabbit liver fibrosis |
| tangxiubin |
| () |
| Abstract: |
| Objective to evaluate the therapeutic effect of IFN-γ on experimental rabbit liver fibrosis by real-time shear wave elastography of application value. Methods Rabbits were randomly divided into liver fibrosis model group and normal control group, and CCl4 olive oil solution、normal saline was used respectively for modeling. IFN-γ was applied to the experimental group for intervention treatment from week 8. At the end of the 12th week, real-time shear wave elastography, serological indexes and pathological examination were performed on the liver of the experimental group and the normal control group. The correlation between Emean value and serological indexes and pathological staging of liver fibrosis after IFN-γ intervention was analyzed, as well as the diagnostic efficacy of the two for liver fibrosis staging. Results Normal liver appearance 、liver fibrosis stage of rabbits and the concentration of alpha-sma per unit area in the normal control group, IFN-γ intervention group and liver fibrosis model group, there were significant differences, and the differences were statistically significant. The Emean values of three different doses of IFN-γ intervention groups were significantly lower than those of the liver fibrosis model group (P < 0.05).The correlation between liver Emean value and liver fibrosis degree after IFN-γ intervention was higher than serological indexes, showing a high linear correlation.Correlation coefficient for (r = 0.935, P = 0.000), and in the evaluation of liver fibrosis stage or S1, S2, S3 or higher, or = S4 area under the ROC curve respectively were greater than HA, CIV, P Ⅲ NP and LN, sensitivity, accuracy and specificity were all > 88.8%. Conclusions Real-time shear wave elastography can be used for quantitative evaluation of liver fibrosis staging after gamma interferon intervention, which can be objective and sensitive effect of IFN-γ in response. |
| Key words: real-time shear wave elastography liver fibrosis serological examination IFN-γ |
