| 摘要: |
| 摘 要 目的 通过研究甲状腺乳头状癌（PTC）超声造影（CEUS）定量参数与微血管密度（MVD）间的相关性，为PTC的微血管评价提供一种非侵入性的术前检测方法。方法 回顾性分析于我院超声科行甲状腺CEUS检查的甲状腺结节患者61例（共61个结节），分析结节的CEUS增强模式时间-强度曲线（TIC）定量参数，并与手术病理结果对照。应用CD31免疫组化法对手术切除的甲状腺结节进行免疫组化染色，计数MVD，Pearson法分析CEUS定量参数与MVD间的相关性。结果 CEUS提示55个PTC结节呈不均匀低增强，其诊断PTC的准确率为90.1%。PTC的TIC峰值强度（PI）及曲线下面积（AUC）分别为（14.47±6.42）dB、（603.1±222.80）dB·s，低于周围正常甲状腺组织的（21.06±5.65）dB、（1025.43±260.37）dB·s，差异均有统计学意义（均P＜0.05）。CD31免疫组化染色计数PTC结节的平均MVD值为（64.99±17.51）条/高倍视野，低于周边正常甲状腺组织的（91.71±7.54）条/高倍视野，差异有统计学意义（P＜0.05）。相关性分析显示PI、AUC与MVD有显著正相关性（r=0.811、0.734，P＜0.001）。结论 CEUS定量分析技术有助于提高PTC的诊断准确性。本研究为术前CEUS有效评价PTC提供了有用的研究基础和实验依据。 |
| 关键词: 超声造影 造影剂 峰值强度 微血管密度 甲状腺乳头状癌 |
| DOI： |
| 投稿时间：2019-06-16修订日期：2020-09-06 |
| 基金项目:国家国际科技合作专项项目( 2015DFA30920) ；重庆市科技研发基地建设计划（国际科技合作）项目( cstc2014gjhz110004) |
|
| Correlation study between contrast-enhanced ultrasound quantitative parameters and microvascular densities in papillary thyroid carcinomas |
| chenping,guo yan li |
| (First Affiliated Hospital of Army Medical University) |
| Abstract: |
| ABSTRACT Objective Our aim is to investigate the correlation between CEUS quantitative parameters and MVD in thyroid papillary carcinoma（PTC），and also to provide a non-invasive preoperative detection method about microvascular evaluation for PTC.Methods Retrospective analysis was performed on 61 patients with thyroid nodules (61 nodules in total) who underwent thyroid CEUS examination in the ultrasound department of our hospital， Quantitative parameters of CEUS enhanced mode time-intensity curve (TIC) of thyroid nodules were analyzed and compared with surgical pathological results. CD31 immunohistochemical staining was performed on the surgically resected thyroid nodules to count MVD. Pearson method was used to analyze the correlation between CEUS quantitative parameters and MVD.Results CEUS indicated that 55 PTC nodules showed heterogeneous and low enhancement pattern. The accuracy of CEUS in diagnosing PTC was 90.1%. The TIC、PI and AUC 55 PTCs were （14.47±6.42）dB and （603.1±222.80）dB?s，respectively，which were lower than （21.06±5.65）dB and （1025.43±260.37） dB?s in the surrounding normal thyroid tissues，and differences were statistically significant（P<0.05）.The mean MVD of CD31 immunohistochemical staining PTC was （64.99±17.51） twigs/HP，which was lower than （91.71±7.54） twigs/HP in surrounding normal thyroid tissue，and the differences were statistically significant（P<0.05）.A significantly positive correlation was observed between PI 、 AUC and MVD in PTC（r=0.811、0.734，P＜0.001）. Conclusion CEUS and quantitative analysis can improve the diagnostic accuracy of thyroid nodules.This study provides useful research basis and experimental basis for the effective evaluation of PTC for CEUS before preoperative. |
| Key words: Contrast-enhanced ultrasound Peak intensity Microvascular density Papillary thyroid carcinoma |
