ABSTRACT Objective To explore the Left ventricular diastolic function with early-onset and late-onset severe preeclampsia（EOSP，LOSP）.Methods Eighty-three patients of SPE were selected as the case group，On the basis of gestational age at the onset of disease，these patients were divided into two groups：the EOSP group who were diagnosed before 34 weeks of gestation and the LOSP group who were diagnosed at or after 34 weeks gestation，fourty-eight EOSP were chosen as the PE1 group，thirty-five LOSP were chosen as the PE2 group,seventy-three healthy pregnancy were selected as the matched group，thirty-six of these were selected as the N1 group who were gestational weeks-matched with PE1，other thirty-seven were selected as the N2 group.Conventional parameters were acquired including：mitral E-wave velocity（E）、mitral A-wave velocity（A）、mitral annulus septal wall and lateral wall e′（eS′、eL′）、a′（aS′、aL′）、isovolumic relaxation time （IVRT） ，and then calculated E/A ratio、eM′、aM′、eM′/aM′ratio and E/eM′ratio.Left atrial maximum volume（LAVmax）was acquired by left atrial volume tracking（LAVT） imaging，and LAVI was obtained indexed to body surface area.Respectively analyzed the differences of parameters between groups.Results Compared with N1 group，in PE1 group E/A、eM′、eM′/aM′decreased，A、E/eM′、IVRT、LAVI increased（P＜0.05）；compared with N2 group，in PE2 group E/A 、eM′、eM′/aM′decreased，A、E/eM′、IVRT、LAVI increased（P＜0.05）；compared with PE1 group，in PE2 group E、E/A 、eM′、E/eM′、IVRT、LAVI decreased，A、 aM′、eM′/aM′increased（P＞0.05）；Compared with N1 group，in N2 group E、A、eM′、aM′、eM′/aM′decreased，E/A、E/eM′、LAVI、IVRT increased（P＞0.05）.Conclusions Left ventricular diastolic function measured by echocardiography was reduced both in EOSP and in LOSP；Compared with LOSP，left ventricular diastolic function was inclined to decrease in EOSP.