Objective Use shear wave elastography to estimate temperature changes in liver to investigate whether shear wave elastography (SWE)can be used to accurately estimate liver temperature during Photothermal ablation. METHODS Fresh porcine liver were heated by a water bath method. SWE and liver histopathology were used to analyze the stiffness of liver tissue from 35 °C to 85 °C. SWE and liver histopathology were used to analyze the change of stiffness of liver after liver tissue maintained a certain temperature for 10 minutes. Results Liver stiffness increased with the increasing of temperature when temperature of Liver was at 55 °C ~ 85 °C, there were statistical difference between the temperature groups (P <0.05). Liver stiffness does not change with time when temperature of Liver was at 50 °C ~ 80 °C,, there was no significant difference of Liver stiffness between before and after temperature maintained for 10 minutes in every temperature group and the (P>0.05). Conclusion When the liver tissue temperature value is 55 °C ~ 80 °C, liver stiffness obtained by SWE could be used as a parameter to valuate temperature changes during Photothermal ablation.