| 摘要: |
| 摘 要 目的 探讨超声造影半定量评估颈动脉斑块内新生血管与循环血中性粒细胞/淋巴细胞比（NLR）的相关性。
方法 选取行颈动脉斑块超声造影检查的受试者132例，依据超声造影半定量评估斑块内新生血管的分级进行分组：1~2级60例（A组）、3级44例（B组）和4级28例（C组）。同时获取三组受试者循环血白细胞计数（WBC）、中性细胞计数（NE）、淋巴细胞计数（LY）及中性粒细胞/淋巴细胞比（NLR）。采用Spearman相关分析斑块超声造影分级与循环血中白细胞各亚型的相关性；Logistic回归进一步分析影响斑块内新生血管的独立危险因素。
结果 三组中脑梗死患者构成比在C组最高，差异有统计学意义（P＜0.05）；A、B、C组间WBC和NE依次增高，而LY依次减低，差异有统计学意义（均P＜0.01）；NLR在A组最小，在C组最大，差异有统计学意义（均P＜0.01）。斑块内新生血管分级与循环血中WBC、NE和NLR呈正相关（r=0.30、0.59和0.77，P均＜0.01），与LY呈负相关（r=-0.50，P＜0.01）。Logistic回归分析提示NLR是斑块内新生血管的独立危险因素，且循环血中NLR每增加1.08，斑块内新生血管分级增加一级。
结论 循环血中NLR与斑块内新生血管密切相关，是其独立危险因素；NLR每增加1.08，斑块内新生血管分级增加一级。 |
| 关键词: 超声检查 造影剂 颈动脉斑块 白细胞 NLR |
| DOI： |
| 投稿时间：2019-07-20修订日期：2020-01-13 |
| 基金项目: |
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| Correlation between carotid plaque CEUS and circulating blood NLR |
| Tanyuting,NIE Fang,Zhu Yangyang,Wang Longli,Wang Yanqing |
| (Lanzhou university second hospital) |
| Abstract: |
| ABSTRACT Objective To investigate the correlation between semi-quantitative contrast-enhanced ultrasonography in evaluating neovascularization in carotid plaques and circulating blood neutrophil / lymphocyte ratio (NLR). Methods A total of 132 subjects who underwent carotid plaque contrast ultrasonography were selected and grouped according to the classification of neovascularization in the plaque by semi-quantitative contrast-enhanced ultrasound: 60 cases in grades 1~2 (group A) and 44 cases in grade 3 (group B ) and 28 cases of grade 4 (group C). Meanwhile, the number of circulating blood white blood cells (WBC), the number of neutral cells(NE),the number of lymphocytes(LY) and neutrophil/lymphocyte ratio(NLR) were obtained from the three groups. Spearman correlation analysis of the correlation between plaque contrast ultrasound classification and leukocyte subtypes in circulating blood. Logistic regression further analyzed the independent risk factors that affected neovascularization within the plaque. Results The proportion of patients with cerebral infarction in the three groups was the highest in group C, and the difference was statistically significant (P ＜0.05); WBC and NE increased sequentially in groups A, B, and C, while LY decreased in order, and the difference was statistically significant (all P＜0.01); NLR was the smallest in group A and the largest in group C. The angiographic grading of carotid plaque was positively correlated with WBC, NE and NLR in blood circulation (r=0.30，0.59 and 0.77, all P＜0.01), but negatively correlated with LY （r= -0.50，P＜0.01). Logistic regression analysis indicated that NLR was an independent risk factor for neovascularization in the plaque. For every 1.08 increase in blood circulation NLR, the angiographic grading was increased by one level. Conclusion NLR in circulating blood is closely related to neovascularization in the plaque and is an independent risk factor. For every 1.08 increase in NLR, the angiographic grading was increased by one level. |
| Key words: Ultrasonography Contrast agent White blood cells NLR |
