Nano-drug delivery system is a promising method to treat many kinds of diseases，especially tumors. Based on the structural changes and modifications of nano-microbubble ，ultrasonic-targeted microbubble destruction (UTMD),as a safe physical targeting method,can enhance tissue and cell membrance permeability,help drug-loaded nano-microbubble enter the targeted tissues and cells,thus improving drug delivery efficiency.In this paper,the latest research progress of UTMD-mediated nano-ultrasound contrast agents was reviewed.