【Abstract】Objective The aim of this study was to determine the capability of three dimensional speckle tracking imaging for evaluation of early myocardial dysfunction triggered by increased left ventricular wall thickness in severe aortic stenosis with normal LV ejection fraction. Methods Forty-five patients with severe aortic stenosis with normal left ventricular ejection fraction (LVEF) were divided into normal LV wall thickness group (A group ,20 cases) and increased LV wall thickness group (B group ,25 cases).Another 30 healthy volunteers matched in age and sex were selected as control group. ALL groups were performed two and three dimensional imaging, LVEF, LVM, GLS, GCS, GAS, GRS were obtained. Left ventricular mass index (LVMI) was calculated. Results GLS, GRS were significantly reduced(P<0.01) and GCS,LVMI were significantly increased(P<0.01) in severe AS groups compared with controls. LVEF and GAS were similar in each groups (P>0.05). B group had lower GLS than A group (P<0.01),but GRS, GAS and GCS were no significant difference(P>0.05).GLS,GRS, GCS and GAS have significant correlation with LVMI(r=0.58,0.31,0.29,0.43,P<0.05). Conclusion When LVEF is normal, the left ventricular systolic function of severe AS patients has been impaired, and patients with increased LV wall thickness and the heavier LVMI were more obvious.